Molecular Detection of Soil-Transmitted Helminths and Enteric Protozoa Infection in Children and Its Association with Household Water and Sanitation in Manhiça District, Southern Mozambique.
Molecular Detection of Soil-Transmitted Helminths and Enteric Protozoa Infection in Children and Its Association with Household Water and Sanitation in Manhiça District, Southern Mozambique.
复制标题
DOI：
10.3390/pathogens10070838
复制
发表时间：
2021-07-03
期刊：
影响因子：
--
通讯作者：
Muñoz J
中科院分区：
文献类型：
--
作者：
Grau-Pujol B;Cuamba I;Jairoce C;Cossa A;Da Silva J;Sacoor C;Dobaño C;Nhabomba A;Mejia R;Muñoz J
肠道寄生虫感染可对儿童的健康造成有害后果。在莫桑比克，自2011年以来，通过大规模药物管理控制了土壤传播蠕虫（STH）感染，但没有针对肠道原生动物的具体控制规划。本研究评估了莫桑比克南部曼希帕拉区接受医疗保健的儿童的STH和原生动物感染，以及其与水和卫生条件的关系。我们在两个健康中心对2至10岁儿童进行了横断面研究（n = 405）。收集每个儿童的粪便样本和元数据。采用多重平行实时定量PCR （qPCR）对样品进行分析。我们拟合logistic回归调整模型来评估STH或原生动物感染与家庭用水和卫生设施使用之间的关系。19%的人感染了至少一种STH， 77.5%的人感染了至少一种肠道原虫。qPCR检测出18.8%的参与者存在肠道多寄生。与家庭自来水相比，有保护或无保护的水井使用儿童至少感染一种原生动物的风险更高（or: 2.59, CI: 1.01-6.65， p值= 0.010;or: 5.21, CI: 1.56-17.46， p值= 0.010）。较高比例的儿童有肠道原虫感染。井水的易损性较高。
Intestinal parasite infections can have detrimental health consequences in children. In Mozambique, soil-transmitted helminth (STH) infections are controlled through mass drug administration since 2011, but no specific control program exists for enteric protozoa. This study evaluates STH and protozoan infections in children attending healthcare in Manhiça district, Southern Mozambique, and its association with water and sanitation conditions. We conducted a cross-sectional study in children between 2 and 10 years old in two health centers (n = 405). A stool sample and metadata were collected from each child. Samples were analyzed by multi-parallel real-time quantitative PCR (qPCR). We fitted logistic regression-adjusted models to assess the association between STH or protozoan infection with household water and sanitation use. Nineteen percent were infected with at least one STH and 77.5% with at least one enteric protozoon. qPCR detected 18.8% of participants with intestinal polyparasitism. Protected or unprotected water well use showed a higher risk for at least one protozoan infection in children (OR: 2.59, CI: 1.01–6.65, p-value = 0.010; OR: 5.21, CI: 1.56–17.46, p-value = 0.010, respectively) compared to household piped water. A high proportion of children had enteric protozoan infections. Well consumable water displayed high risk for that.
登录
查看更多内容
影响因子：
3.8
作者：
Meurs L;Polderman AM;Vinkeles Melchers NV;Brienen EA;Verweij JJ;Groosjohan B;Mendes F;Mechendura M;Hepp DH;Langenberg MC;Edelenbosch R;Polman K;van Lieshout L
通讯作者：
van Lieshout L
影响因子：
8.4
作者：
Acacio, Sozinho;Nhampossa, Tacilta;Bassat, Quique
通讯作者：
Bassat, Quique
影响因子：
1
作者：
Ayele, Dawit;Zewotir, Temesgen;Mwambi, Henry
通讯作者：
Mwambi, Henry
DOI：
10.4269/ajtmh.2007.76.522
发表时间：
2007-03-01
影响因子：
3.3
作者：
Mandomando, Inacio M.;Macete, Eusebio V.;Gascon, Joaquim
通讯作者：
Gascon, Joaquim
影响因子：
3.7
作者：
Bauhofer AFL;Cossa-Moiane ILC;Marques SDA;Guimarães ELAM;Munlela BA;Anapakala EM;Chiláule JJ;Cassocera M;Langa JS;Chissaque A;Sambo JAM;Manhique-Coutinho LV;Bero DM;Kellogg TA;Gonçalves LAP;de Deus N
通讯作者：
de Deus N