Relationship between physical occupational exposures and health on semen quality: data from the Longitudinal Investigation of Fertility and the Environment (LIFE) Study.
Relationship between physical occupational exposures and health on semen quality: data from the Longitudinal Investigation of Fertility and the Environment (LIFE) Study.
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DOI：
10.1016/j.fertnstert.2015.02.010
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发表时间：
2015-05
影响因子：
6.7
通讯作者：
Louis, Germaine M. Buck
中科院分区：
文献类型：
--
作者：
Eisenberg, Michael L.;Chen, Zhen;Ye, Aijun;Louis, Germaine M. Buck
研究一组试图怀孕的男性的职业、健康和精液质量之间的关系。观察性前瞻性队列研究密歇根州/得克萨斯州16个县共有501对夫妇在试图怀孕时停止避孕，随访1年; 473名男性（94%）提供了一份精液样本，80%提供了第二份样本。没有。通过在家采集精液并在次日进行分析/定量获得精液数据。总共有456名男性的完整数据，平均年龄为31.8岁。与工作相关的重度劳累与较低的精液浓度和精子总数相关。13%的男性报告说，他们在工作中表现出少精症，而6%的人没有报告工作场所的劳累。轮班工作、夜班工作、振动、噪音、高温和久坐与精液质量无关。与血压正常的男性相比，高血压男性的严格形态学评分显著较低（17% vs. 21%）。相反，高脂血症、糖尿病和合并症与精液质量无关。男性服用的药物数量作为健康状况的代表与精液质量有关。药物数量与精子计数呈负相关（pTrend <0.05）。职业劳累、高血压和用药次数与精液质量呈负相关。由于这些都是潜在的可改变的因素，进一步的研究应该确定治疗或停止是否可以提高男性生育力。Eunice Kennedy Shriver国家儿童健康和人类发展研究所的校内研究（合同编号N 01-HD-3-3355、N 01-HD-3-3356和N 01-HD-3-3358）。
To study the relationship between occupation, health, and semen quality in a cohort of men attempting to conceive. Observational prospective cohort Sixteen Michigan/Texas counties A total of 501 couples discontinuing contraception were followed for 1 year while trying to conceive; 473 men (94%) provided one semen sample, and 80% provided a second sample. None. Semen data obtained through at home semen collection with next day analysis/quantification. In all, complete data were available for 456 men with a mean age of 31.8 years. Work related heavy exertion was consistently associated lower semen concentration and total sperm count. 13% of men who reported heavy exertion displayed oligospermia, compared to 6% who did not report workplace exertion. Shift work, night work, vibration, noise, heat, and prolonged sitting were not associated with semen quality. Men with high blood pressure had significantly lower strict morphology scores compared to normotensive men (17% vs. 21%). In contrast, hyperlipidemia, diabetes, and composite of total comorbidities were not associated with semen quality. The number of medications a man was taking as a proxy of health status was associated with semen quality. There was a negative association between number of medications and sperm count (pTrend <0.05). A negative relationship between occupational exertion, hypertension, and the number of medications with semen quality was identified. As these are potentially modifiable factors, further research should determine if treatment or cessation may improve male fecundity. Intramural research of the Eunice Kennedy Shriver National Institute of Child Health and Human Development (Contracts #N01-HD-3-3355, N01-HD-3-3356 and N01-HD-3-3358).
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影响因子：
3.4
作者：
Håkonsen LB;Thulstrup AM;Aggerholm AS;Olsen J;Bonde JP;Andersen CY;Bungum M;Ernst EH;Hansen ML;Ernst EH;Ramlau-Hansen CH
通讯作者：
Ramlau-Hansen CH
重金属和夫妇的生命研究。
影响因子：
8.8
作者：
Buck Louis GM;Sundaram R;Schisterman EF;Sweeney AM;Lynch CD;Gore-Langton RE;Chen Z;Kim S;Caldwell KL;Barr DB
通讯作者：
Barr DB
影响因子：
10.4
作者：
Buck Louis GM;Sundaram R;Schisterman EF;Sweeney AM;Lynch CD;Gore-Langton RE;Maisog J;Kim S;Chen Z;Barr DB
通讯作者：
Barr DB
影响因子：
3.3
作者：
Hjollund, NHI;Storgaard, L;Olsen, J
通讯作者：
Olsen, J
影响因子：
6.1
作者：
Oliva, A;Spira, A;Multigner, L
通讯作者：
Multigner, L