Persistent environmental pollutants and couple fecundity: the LIFE study.
Persistent environmental pollutants and couple fecundity: the LIFE study.
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DOI：
10.1289/ehp.1205301
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发表时间：
2013-02
影响因子：
10.4
通讯作者：
Barr DB
中科院分区：
文献类型：
--
作者：
Buck Louis GM;Sundaram R;Schisterman EF;Sweeney AM;Lynch CD;Gore-Langton RE;Maisog J;Kim S;Chen Z;Barr DB
背景资料：有证据表明，持久性环境污染物可能是生殖毒物，这突出表明有必要对已测量接触情况的夫妇进行前瞻性研究。目的：我们研究了选定的持久性污染物与夫妇生育能力（通过怀孕时间测量）之间的关系。研究方法：一组501对夫妇停止避孕怀孕的前瞻性随访12个月试图怀孕或直到人绒毛膜促性腺激素（hCG）测试证实怀孕。夫妇完成日常生活方式的日志，并提供生物标本的定量9有机氯农药，1多溴联苯，10多溴二苯醚，36多氯联苯（PCB），和7全氟化学品（PFC）在血清中。使用离散时间的考克斯模型，我们分别估计了每个伴侣的浓度的受精率比值比（FO）和95% CI，调整了年龄、体重指数、血清可替宁、血脂（PFC除外）和研究中心（密歇根州或德克萨斯州）;敏感性模型进一步调整了入组前的左截断或避孕时间（≤ 2个月）。结果如下：在雌性动物中，多氯联苯同系物118、167、209和全氟辛烷磺酰胺的生育能力的调整降低与对数转换血清浓度的标准差增加相关，范围在18%至21%之间;在雄性动物中，p，p ′-DDE和多氯联苯同系物138、156、157、167、170、172和209的调整降低在17%至29%之间。在女性和男性中，PCB 167（FOR = 0.79; 95% CI：0.64，0.97）和PCB 138（FOR = 0.71; 95% CI：0.52，0.98）的相关性最强。结论：在这项基于夫妇的前瞻性队列研究中，对女性和男性伴侣进行了孕前登记和暴露量化，我们观察到一部分持久性环境化学物质与生殖力降低相关。
Background: Evidence suggesting that persistent environmental pollutants may be reproductive toxicants underscores the need for prospective studies of couples for whom exposures are measured. Objectives: We examined the relationship between selected persistent pollutants and couple fecundity as measured by time to pregnancy. Methods: A cohort of 501 couples who discontinued contraception to become pregnant was prospectively followed for 12 months of trying to conceive or until a human chorionic gonadotrophin (hCG) test confirmed pregnancy. Couples completed daily journals on lifestyle and provided biospecimens for the quantification of 9 organochlorine pesticides, 1 polybrominated biphenyl, 10 polybrominated diphenyl ethers, 36 polychlorinated biphenyls (PCBs), and 7 perfluorochemicals (PFCs) in serum. Using Cox models for discrete time, we estimated fecundability odds ratios (FORs) and 95% CIs separately for each partner’s concentrations adjusting for age, body mass index, serum cotinine, serum lipids (except for PFCs), and study site (Michigan or Texas); sensitivity models were further adjusted for left truncation or time off of contraception (≤ 2 months) before enrollment. Results: The adjusted reduction in fecundability associated with standard deviation increases in log-transformed serum concentrations ranged between 18% and 21% for PCB congeners 118, 167, 209, and perfluorooctane sulfonamide in females; and between 17% and 29% for p,p´-DDE and PCB congeners 138, 156, 157, 167, 170, 172, and 209 in males. The strongest associations were observed for PCB 167 (FOR 0.79; 95% CI: 0.64, 0.97) in females and PCB 138 (FOR = 0.71; 95% CI: 0.52, 0.98) in males. Conclusions: In this couple-based prospective cohort study with preconception enrollment and quantification of exposures in both female and male partners, we observed that a subset of persistent environmental chemicals were associated with reduced fecundity.
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通讯作者：
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