Heavy metals and couple fecundity, the LIFE Study.
Heavy metals and couple fecundity, the LIFE Study.
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重金属和夫妇的生命研究。
DOI：
10.1016/j.chemosphere.2012.01.017
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发表时间：
2012-06
期刊：
影响因子：
8.8
通讯作者：
Barr DB
中科院分区：
文献类型：
--
作者：
Buck Louis GM;Sundaram R;Schisterman EF;Sweeney AM;Lynch CD;Gore-Langton RE;Chen Z;Kim S;Caldwell KL;Barr DB
环境相关浓度的重金属对夫妻生育能力的影响虽然普遍存在，但研究有限。2005-2009年，招募了501对希望怀孕并停止避孕的夫妇（n=501），要求他们完成访谈并提供血样，用于电感耦合等离子体质谱法测定镉（μg/L）、铅（μg/dL）和汞（μg/L）。夫妇们完成了关于生活方式和性生活的日常日志，以及女性的月经和怀孕测试。研究人员对这些夫妇进行了12个月的跟踪调查，直到他们怀孕为止。根据年龄、体重指数、可替宁和与女性和男性接触相关的血清脂质，估计生育能力优势比（FORs）和95%置信区间（CIs）。FORs <1表示怀孕时间较长。在调整后的模型中，观察到女性镉（0.78;95% CI 0.63-0.97）和男性铅（0.85;95% CI 0.73-0.98）浓度的FORs降低。当共同模拟夫妻暴露时，只有男性铅浓度显著降低了FOR (0.82; 95% CI 0.68, 0.97)，尽管女性镉的FOR仍然<1 （0.80;95% CI 0.64, 1.00）。这一前瞻性的夫妇为基础的队列纵向捕获时间到怀孕是提示镉和铅的生殖毒性在环境相关浓度。
The effect of heavy metals at environmentally relevant concentrations on couple fecundity has received limited study despite ubiquitous exposure. In 2005–2009, couples (n=501) desiring pregnancy and discontinuing contraception were recruited and asked to complete interviews and to provide blood specimens for the quantification of cadmium (μg/L), lead (μg/dL) and mercury (μg/L) using inductively coupled plasma-mass spectrometry. Couples completed daily journals on lifestyle and intercourse along with menstruation and pregnancy testing for women. Couples were followed for 12 months or until pregnant. Fecundability odds ratios (FORs) and 95% confidence intervals (CIs) were estimated adjusting for age, body mass index, cotinine, and serum lipids in relation to female then male exposures. FORs <1 denote a longer time to pregnancy. In adjusted models, reduced FORs were observed for both female cadmium (0.78; 95% CI 0.63–0.97) and male lead (0.85; 95% CI 0.73–0.98) concentrations. When jointly modeling couples’ exposures, only male lead concentration significantly reduced the FOR (0.82; 95% CI 0.68, 0.97), though the FOR remained <1 for female cadmium (0.80; 95% CI 0.64, 1.00). This prospective couple based cohort with longitudinal capture of time to pregnancy is suggestive of cadmium and lead’s reproductive toxicity at environmentally relevant concentrations.
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影响因子：
7.7
作者：
DEMOUZON, J;SPIRA, A;SCHWARTZ, D
通讯作者：
SCHWARTZ, D
影响因子：
10.4
作者：
Harley KG;Marks AR;Chevrier J;Bradman A;Sjödin A;Eskenazi B
通讯作者：
Eskenazi B
影响因子：
13.3
作者：
Caserta, D.;Mantovani, A.;Moscarini, M.
通讯作者：
Moscarini, M.
影响因子：
6.1
作者：
Behre, HM;Kuhlage, J;Nieschlag, E
通讯作者：
Nieschlag, E
DOI：
10.1097/ede.0b013e31818ef47e
发表时间：
2009-01
期刊：
Epidemiology (Cambridge, Mass.)
影响因子：
--
作者：
Cooney MA;Buck Louis GM;Sundaram R;McGuiness BM;Lynch CD
通讯作者：
Lynch CD