OPTICAL COHERENCE TOMOGRAPHY–BASED CORRELATION BETWEEN CHOROIDAL THICKNESS AND DRUSEN LOAD IN DRY AGE-RELATED MACULAR DEGENERATION
OPTICAL COHERENCE TOMOGRAPHY–BASED CORRELATION BETWEEN CHOROIDAL THICKNESS AND DRUSEN LOAD IN DRY AGE-RELATED MACULAR DEGENERATION
复制标题
基于光学相干断层扫描的干性年龄相关性黄斑变性脉络膜厚度与玻璃疣负荷之间的相关性
DOI：
10.1097/iae.0b013e31827d266e
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发表时间：
2013
期刊：
影响因子：
--
通讯作者：
F. Forooghian
中科院分区：
文献类型：
--
作者：
Ashley Ko;Sijia Cao;Kaivon L Pakzad;P. Brasher;A. Merkur;D. Albiani;A. Kirker;J. Cui;J. Matsubara;F. Forooghian
目的：光谱域光学相干断层扫描可用于测量脉络膜厚度和玻璃体负荷。作者使用光谱域光学相干断层扫描进行了一项探索性研究，以确定干性老年性黄斑变性患者脉络膜厚度和玻璃体负荷之间是否存在相关性。方法：44例干性老年性黄斑变性患者入选。利用光谱域光学相干断层扫描仪的自动软件算法确定玻璃膜面积和体积，并采用增强深度成像技术测量脉络膜厚度。相关性通过多变量和单变量分析来确定。结果：脉络膜厚度与玻璃体负荷呈负相关(r=−0.35，P=0.0 4)。玻璃体负荷量与视力呈正相关(r=0.32，P=0.04)。脉络膜厚度与视力呈正相关(r=−0.22，P=0.21)。结论：光谱域光学相干断层扫描可用于评价玻璃体挫伤负荷与脉络膜厚度的相关性，两者均与视力有关。这些结果的测量可以作为常规临床护理和干性老年性黄斑变性患者临床试验的重要结果参数。
Purpose: Spectral domain optical coherence tomography can be used to measure both choroidal thickness and drusen load. The authors conducted an exploratory study using spectral domain optical coherence tomography to determine if a correlation between choroidal thickness and drusen load exists in patients with dry age-related macular degeneration. Methods: Forty-four patients with dry age-related macular degeneration were recruited. The drusen area and volume were determined using the automated software algorithm of the spectral domain optical coherence tomography device, and choroidal thickness was measured using enhanced depth imaging. Correlations were determined using multivariable and univariable analyses. Results: The authors found an inverse correlation between choroidal thickness and drusen load (r = −0.35, P = 0.04). Drusen load was also correlated with visual acuity (r = 0.32, P = 0.04). A correlation between choroidal thickness and visual acuity was suggested (r = −0.22, P = 0.21). Conclusion: Spectral domain optical coherence tomography can be used to assess the correlation between drusen load and choroidal thickness, both of which show a relationship with visual acuity. The measurement of these outcomes may serve as important outcome parameters in routine clinical care and in clinical trials for patients with dry age-related macular degeneration.
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影响因子：
4.4
作者：
Zhang, Li;Lee, Kyungmoo;Abramoff, Michael D.
通讯作者：
Abramoff, Michael D.
影响因子：
--
作者：
J. Grunwald;S. Hariprasad;J. Dupont
通讯作者：
J. Grunwald;S. Hariprasad;J. Dupont
影响因子：
13.7
作者：
Schuman SG;Koreishi AF;Farsiu S;Jung SH;Izatt JA;Toth CA
通讯作者：
Toth CA
影响因子：
4.4
作者：
R. Linsenmeier;L. Padnick-Silver
通讯作者：
R. Linsenmeier;L. Padnick-Silver
影响因子：
4.2
作者：
Manjunath, Varsha;Goren, Jordana;Fujimoto, James G.;Duker, Jay S.
通讯作者：
Duker, Jay S.