Hot flashes and cardiac vagal control: a link to cardiovascular risk?
Hot flashes and cardiac vagal control: a link to cardiovascular risk?
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DOI：
10.1097/gme.0b013e3181c7dea7
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发表时间：
2010-05
期刊：
影响因子：
--
通讯作者：
Matthews KA
中科院分区：
文献类型：
--
作者：
Thurston RC;Christie IC;Matthews KA
对潮热的生理机制的理解是不完整的。自主神经系统一直被假设在潮热中起作用，但在实验上受到的关注有限。此外，新出现的研究将潮热与心血管风险联系起来。高频心率变异性降低(HF-HRV)是迷走神经控制心率的指标，与心血管事件有关。我们假设HF-HRV的降低会发生在潮热期间，相对于潮热前后的时间段。30名年龄在40-60岁的围绝经期和绝经后妇女，报告≥每天4次潮热，接受了实验室潮热刺激试验，并测量了胸骨皮肤电导和心电图。潮热的报告和鉴定，从胸骨皮肤传导性。使用心率时间序列的频谱分析来估计HF-HRV。通过混合效应模型，将热闪期间的五分钟间隔与热闪之前和之后的两个非闪光时段进行比较。与潮热前(b=0.18，SE=0.05p=0.0001)和潮热后(b=0.16，SE=0.05，p=0.002)相比，潮热期间心率变异性显著降低(b=0.16，SE=0.05，p=0.002)。考虑到自己报告的潮热，研究结果没有变化。潮热期间心脏迷走神经控制力显著下降，这可能有助于阐明潮热的生理机制。在理解潮热与心血管风险之间的联系机制时，自主神经系统可能需要更多的关注。
The understanding of the physiology of hot flashes is incomplete. The autonomic nervous system has been hypothesized to play a role in hot flashes but has received limited empirical attention. Further, emerging research has linked hot flashes to cardiovascular risk. Reduced high frequency heart rate variability (HF-HRV), an index of vagal control of heart rate, has been associated with cardiovascular events. We hypothesized that decreases in HF-HRV would occur during hot flashes relative to periods preceding and following the hot flash. Thirty peri- and postmenopausal women ages 40–60 reporting ≥4 hot flashes/day underwent laboratory hot flash provocation testing, with measurement of sternal skin conductance and electrocardiogram. Hot flashes were reported and identified from sternal skin conductance. HF-HRV was estimated using spectral analysis of the heart rate time series. The five minute interval during the hot flash was compared to two non-flash periods prior and following the hot flash via mixed effects models. HRV was significantly decreased during hot flashes relative to periods prior to (b=0.18, SE=0.05 p=0.0001) and after (b=0.16, SE=0.05, p=0.002) physiologically-measured hot flashes, controlling for age, race, education, task condition, menopausal status, task, hypertension status, diabetes status, physical activity, body mass index, smoking, and anxiety. Findings were unchanged considering self-reported hot flashes. Significant decreases in cardiac vagal control occurred during hot flashes, which may help shed light on the physiology of hot flashes. The autonomic nervous system may deserve greater attention in understanding the mechanisms linking hot flashes to cardiovascular risk.
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影响因子：
12.7
作者：
Gold, Ellen B.;Colvin, Alicia;Matthews, Karen
通讯作者：
Matthews, Karen
影响因子：
5
作者：
PAFFENBARGER, RS;WING, AL;HYDE, RT
通讯作者：
HYDE, RT
DOI：
10.1111/j.1471-0528.1981.tb02230.x
发表时间：
1981-01-01
期刊：
BRITISH JOURNAL OF OBSTETRICS AND GYNAECOLOGY
影响因子：
--
作者：
GINSBURG, J;SWINHOE, J;OREILLY, B
通讯作者：
OREILLY, B
影响因子：
5.8
作者：
Randolph, JF;Sowers, MF;Matthews, KA
通讯作者：
Matthews, KA
DOI：
10.1097/gme.0b013e31819c11e4
发表时间：
2009-07
期刊：
Menopause (New York, N.Y.)
影响因子：
--
作者：
Huang AJ;Sawaya GF;Vittinghoff E;Lin F;Grady D
通讯作者：
Grady D