Self-Healing Injectable Hydrogels for Tissue Regeneration.
Self-Healing Injectable Hydrogels for Tissue Regeneration.
复制标题
用于组织再生的自愈注射水凝胶。
DOI：
10.1021/acs.chemrev.2c00179
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发表时间：
2023-01-25
期刊：
影响因子：
62.1
通讯作者：
Leeuwenburgh, Sander C. G.
中科院分区：
文献类型：
--
作者：
Bertsch, Pascal;Diba, Mani;Mooney, David J.;Leeuwenburgh, Sander C. G.
生物材料具有自我修复和恢复结构完整性的能力，在生物医学领域具有广泛的应用前景。在过去的十年里，一种新的自我修复生物材料迅速出现，通常被称为可注射的，或者在3D打印的背景下可打印的。这些自我修复的可注射生物材料，主要是基于可逆化学的水凝胶和其他软凝聚态物质，能够在剪切应力下暂时流化，随后恢复其原始机械性能。与传统的生物材料相比，可自我修复的注射水凝胶具有明显的优势。最值得注意的是，它们可以通过狭窄的注射器以局部靶向和微创的方式施用，而无需进行侵入性手术。它们的可塑性允许对患者进行特定的干预，并显示出个性化医疗的巨大前景。由于其粘弹性和弥漫性，注射水凝胶可以通过多种方式促进组织再生，从简单的机械支持，细胞或治疗药物的时空控制递送，到局部招募和调节宿主细胞以促进组织再生。因此，自愈注射水凝胶已经在许多尖端的组织再生策略的最前沿。本研究对用于组织再生的可注射自愈水凝胶的现状进行了综述。作为这一令人兴奋的研究领域进一步成熟的关键挑战，我们确定了(i)水凝胶的自愈性和可注射性与其物理稳定性之间的权衡，（ii）对自愈性可注射水凝胶的流变特性和定量基准缺乏共识，特别是关于注射器中的毛细管流动。以及（iii）关于转化为用于特定组织再生的治疗有效制剂的实际限制。因此，在这里，我们(i)回顾了自愈注射水凝胶的化学和物理设计策略，（ii）为其流变分析提供了实用指南，（iii）展示了它们在各种组织再生和复杂组织和类器官3D打印中的适用性。
Biomaterials with the ability to self-heal and recover their structural integrity offer many advantages for applications in biomedicine. The past decade has witnessed the rapid emergence of a new class of self-healing biomaterials commonly termed injectable, or printable in the context of 3D printing. These self-healing injectable biomaterials, mostly hydrogels and other soft condensed matter based on reversible chemistry, are able to temporarily fluidize under shear stress and subsequently recover their original mechanical properties. Self-healing injectable hydrogels offer distinct advantages compared to traditional biomaterials. Most notably, they can be administered in a locally targeted and minimally invasive manner through a narrow syringe without the need for invasive surgery. Their moldability allows for a patient-specific intervention and shows great prospects for personalized medicine. Injected hydrogels can facilitate tissue regeneration in multiple ways owing to their viscoelastic and diffusive nature, ranging from simple mechanical support, spatiotemporally controlled delivery of cells or therapeutics, to local recruitment and modulation of host cells to promote tissue regeneration. Consequently, self-healing injectable hydrogels have been at the forefront of many cutting-edge tissue regeneration strategies. This study provides a critical review of the current state of self-healing injectable hydrogels for tissue regeneration. As key challenges toward further maturation of this exciting research field, we identify (i) the trade-off between the self-healing and injectability of hydrogels vs their physical stability, (ii) the lack of consensus on rheological characterization and quantitative benchmarks for self-healing injectable hydrogels, particularly regarding the capillary flow in syringes, and (iii) practical limitations regarding translation toward therapeutically effective formulations for regeneration of specific tissues. Hence, here we (i) review chemical and physical design strategies for self-healing injectable hydrogels, (ii) provide a practical guide for their rheological analysis, and (iii) showcase their applicability for regeneration of various tissues and 3D printing of complex tissues and organoids.
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