Gender differences in the prospective associations of self-reported sleep quality with biomarkers of systemic inflammation and coagulation: findings from the Heart and Soul Study.
Gender differences in the prospective associations of self-reported sleep quality with biomarkers of systemic inflammation and coagulation: findings from the Heart and Soul Study.
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自我报告的睡眠质量与全身炎症和凝血生物标志物的前瞻性关联的性别差异：心与灵魂研究的结果。
DOI：
10.1016/j.jpsychires.2013.05.004
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发表时间：
2013
影响因子：
4.8
通讯作者：
Whooley,MaryA
中科院分区：
文献类型：
--
作者：
Prather,AricA;Epel,ElissaS;Cohen,BethE;Neylan,ThomasC;Whooley,MaryA
全身炎症被认为是睡眠不良与心血管疾病之间联系的潜在机制。本研究的目的是调查自我报告的睡眠质量与冠心病 (CHD) 相关的炎症和凝血生物标志物的横断面和前瞻性关联，并探讨这些关联在男性和女性之间是否存在差异。为此，我们在基线时对 980 名患有先心病的参与者和 626 名患有 5 年随访的参与者进行了睡眠质量和炎症标志物的测量，包括白细胞介素 6 (IL-6)、高敏 C 反应蛋白 (CRP) 和纤维蛋白原的循环水平。在整个样本中，横断面和前瞻性分析中主观睡眠质量与炎症标志物无关。然而，在性别分层分析中，调整年龄、种族、教育程度、体重指数和定期打鼾后，基线时主观睡眠质量较差与 IL-6 (b= 0.14，SE = 0.05，p= 0.003)、CRP (b= 0.21，SE = 0.09，p= 0.02) 和纤维蛋白原 5 年增加相关。 （b= 18.02，SE = 7.62，p= 0.02）在女性中，但在男性中则不然。这些关联仍然独立于生活方式/心理社会因素、医疗合并症、药物使用和心脏功能。报告基线睡眠障碍的女性，其特征是早上起得太早，循环中的 IL-6 也显示出 5 年的显着增加，并且经得起协变量调整。需要进一步的研究来阐明主观睡眠质量与炎症和凝血标志物之间性别特异性关联的途径，因为这可能有助于澄清先心病的性别差异。
Systemic inflammation is proposed as a putative mechanism underlying the link between poor sleep and cardiovascular disease. The aim of present study was to investigate the cross-sectional and prospective associations of self-reported sleep quality with biomarkers of inflammation and coagulation implicated in coronary heart disease (CHD) and to explore whether these associations differed between men and women. To this end, measures of sleep quality and markers of inflammation, including circulating levels of interleukin-6 (IL-6), high-sensitivity C-reactive protein (CRP), and fibrinogen were assessed at baseline in 980 participants with established CHD and 626 at 5-year follow-up. In the sample as a whole, subjective sleep quality was unrelated to inflammatory markers in cross-sectional and prospective analyses. However, in gender stratified analyses, adjusting for age, ethnicity, education, body mass index, and regular snoring, poorer subjective sleep quality at baseline was prospectively associated with 5-year increases in IL-6 (b= 0.14, SE = 0.05,p= 0.003), CRP (b= 0.21, SE = 0.09,p= 0.02), and fibrinogen (b= 18.02, SE = 7.62,p= 0.02) in women but not men. These associations remained independent of lifestyle/psychosocial factors, medical comorbidities, medication use, and cardiac function. Women who reported baseline sleep disturbances characterized by a tendency to wake up too early in the morning also showed significant 5-year increases in circulating IL-6 that withstood covariate adjustment. Further research is necessary to elucidate the pathways that underlie gender-specific associations between subjective sleep quality and markers of inflammation and coagulation as this may help clarify gender disparities in CHD.
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影响因子：
9.1
作者：
Mullington, Janet M.;Haack, Monika;Toth, Maria;Serrador, Jorge A.;Meier-Ewert, Hans K.
通讯作者：
Meier-Ewert, Hans K.
影响因子：
4.7
作者：
Leineweber, C;Kecklund, G;Orth-Gomér, K
通讯作者：
Orth-Gomér, K
影响因子：
16.2
作者：
Ayas, NT;White, DP;Hu, FB
通讯作者：
Hu, FB
内分泌学和代谢学原理与实践
DOI：
--
发表时间：
1990
期刊：
影响因子：
--
作者：
K. L. Becker
通讯作者：
K. L. Becker
纤维蛋白原和心血管疾病的风险：Kannel WB、Wolf PA、Castelli WP 等 JAMA 258：1183–1186 Sep 1987
影响因子：
6.2
作者：
V. Nguyen
通讯作者：
V. Nguyen