Dynamic oxygen-enhanced MRI of cerebrospinal fluid.
Dynamic oxygen-enhanced MRI of cerebrospinal fluid.
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DOI：
10.1371/journal.pone.0100723
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发表时间：
2014
期刊：
影响因子：
3.7
通讯作者：
Togashi K
中科院分区：
文献类型：
--
作者：
Mehemed TM;Fushimi Y;Okada T;Yamamoto A;Kanagaki M;Kido A;Fujimoto K;Sakashita N;Togashi K
氧的顺磁特性导致组织的纵向弛豫率增加，这是通过其T1缩短效应实现的。由于这种效应，MRI已被用于研究包括脑脊液（CSF）空间在内的各种身体部位中与氧相关的信号强度变化。CSF的氧增强主要使用具有相对较长时间分辨率的MRI序列（如FLAIR）和T1值计算进行研究。在这项研究中，15名健康志愿者使用快速高级自旋回波MRI序列进行扫描，有和没有反转恢复脉冲，以动态跟踪CSF的氧增强。我们还重点讨论了脑沟和脑室CSF氧增强的差异。我们的研究结果表明，给氧后的CSF信号显示，在两个序列中，脑沟CSF和脑室CSF的信号均快速增加，与脑室CSF相比，脑沟CSF的增加具有统计学显著性。传统上认为CSF主要由脑室脉络丛形成并在蛛网膜绒毛处吸收，然而，也认为脑小动脉有助于CSF的产生和吸收，并且在确切机制方面仍存在争议。我们的研究结果表明，脑沟CSF中的快速氧增强，这可能表明吸入的氧气可以迅速扩散到脑沟CSF空间，这可能是由于脑沟上丰富的软脑膜小动脉。
Oxygen causes an increase in the longitudinal relaxation rate of tissues through its T1-shortening effect owing to its paramagnetic properties. Due to such effects, MRI has been used to study oxygen-related signal intensity changes in various body parts including cerebrospinal fluid (CSF) space. Oxygen enhancement of CSF has been mainly studied using MRI sequences with relatively longer time resolution such as FLAIR, and T1 value calculation. In this study, fifteen healthy volunteers were scanned using fast advanced spin echo MRI sequence with and without inversion recovery pulse in order to dynamically track oxygen enhancement of CSF. We also focused on the differences of oxygen enhancement at sulcal and ventricular CSF. Our results revealed that CSF signal after administration of oxygen shows rapid signal increase in both sulcal CSF and ventricular CSF on both sequences, with statistically significant predominant increase in sulcal CSF compared with ventricular CSF. CSF is traditionally thought to mainly form from the choroid plexus in the ventricles and is absorbed at the arachnoid villi, however, it is also believed that cerebral arterioles contribute to the production and absorption of CSF, and controversy remains in terms of the precise mechanism. Our results demonstrated rapid oxygen enhancement in sulcal CSF, which may suggest inhaled oxygen may diffuse into sulcal CSF space rapidly probably due to the abundance of pial arterioles on the brain sulci.
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影响因子：
19.7
作者：
Yamada, Shinya;Miyazaki, Mitsue;McComb, J. Gordon
通讯作者：
McComb, J. Gordon
影响因子：
19.7
作者：
BHADELIA, RA;BOGDAN, AR;HEILMAN, CB
通讯作者：
HEILMAN, CB
影响因子：
--
作者：
Cohen, Benjamin;Voorhees, Abram;Wei, Timothy
通讯作者：
Wei, Timothy
影响因子：
3.3
作者：
O'Connor, James P. B.;Jackson, Alan;Parker, Geoff J. M.
通讯作者：
Parker, Geoff J. M.
影响因子：
4.4
作者：
Tadamura, E;Hatabu, H;Edelman, RR
通讯作者：
Edelman, RR