Genetic variation in responses to dietary restriction--an unbiased tool for hypothesis testing.
Genetic variation in responses to dietary restriction--an unbiased tool for hypothesis testing.
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DOI：
10.1016/j.exger.2013.03.010
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发表时间：
2013-10
影响因子：
3.9
通讯作者：
Nelson, James F.
中科院分区：
文献类型：
--
作者：
Liao, Chen-Yu;Johnson, Thomas E.;Nelson, James F.
饮食限制(DR)可在多种动物模型中延长寿命。理解DR如何调节寿命和衰老相关功能障碍的一个主要障碍是与DR相关的多种生理和分子变化，揭示它们对DR长寿效应的重要性仍然是一个重大挑战。从这个角度出发，我们回顾了多个重组近交系(RI)小鼠品系对DR反应的显著遗传变异。我们说明如何利用这种遗传变异来探索DR延长寿命的中介机制，并揭示其作为一种干预措施的局限性。RI菌株在其寿命和对DR的生理反应方面表现出显著的差异，定量遗传和统计工具可以利用这种表型变化来探索生理和分子变化的重要性，这些变化被假设在DR介导的寿命延长中发挥作用。
Dietary restriction (DR) extends lifespan in a wide range of animal models. A major obstacle to understanding how DR modulates lifespan and aging-related dysfunction is the multiplicity of physiological and molecular changes associated with DR. Unraveling their importance to the longevity effect of DR remains a major challenge. In this Perspective, we review the marked genetic variation in the response to DR of multiple recombinant inbred (RI) mouse strains. We illustrate how this genetic variation can be exploited to probe the mechanisms mediating lifespan extension by DR, as well as uncover its limits as an intervention. RI strains exhibit marked variation in their lifespan as well as physiological responses to DR. Quantitative genetic and statistical tools can use this phenotypic variation to probe the importance of physiological and molecular changes that have been hypothesized to play roles in DR-mediated lifespan extension.
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DOI：
10.1126/science.1173635
发表时间：
2009-07-10
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Colman RJ;Anderson RM;Johnson SC;Kastman EK;Kosmatka KJ;Beasley TM;Allison DB;Cruzen C;Simmons HA;Kemnitz JW;Weindruch R
通讯作者：
Weindruch R
DOI：
10.1073/pnas.79.21.6603
发表时间：
1982-01-01
期刊：
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES
影响因子：
--
作者：
JOHNSON, TE;WOOD, WB
通讯作者：
WOOD, WB
影响因子：
64.8
作者：
Mattison, Julie A.;Roth, George S.;Beasley, T. Mark;Tilmont, Edward M.;Handy, April M.;Herbert, Richard L.;Longo, Dan L.;Allison, David B.;Young, Jennifer E.;Bryant, Mark;Barnard, Dennis;Ward, Walter F.;Qi, Wenbo;Ingram, Donald K.;de Cabo, Rafael
通讯作者：
de Cabo, Rafael
影响因子：
7.8
作者：
Harper, James M.;Leathers, Charles W.;Austad, Steven N.
通讯作者：
Austad, Steven N.
影响因子：
64.8
作者：
Bartke, A;Wright, JC;Roth, GS
通讯作者：
Roth, GS