Ginsenoside Rc from Panax Ginseng Ameliorates Palmitate-Induced UB/OC-2 Cochlear Cell Injury.
Ginsenoside Rc from Panax Ginseng Ameliorates Palmitate-Induced UB/OC-2 Cochlear Cell Injury.
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DOI：
10.3390/ijms24087345
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发表时间：
2023-04-16
影响因子：
5.6
通讯作者：
Bettaieb, Ahmed
中科院分区：
文献类型：
--
作者：
Gill, Nicholas B. B.;Dowker-Key, Presley D. D.;Hubbard, Katelin;Voy, Brynn H. H.;Whelan, Jay;Hedrick, Mark;Bettaieb, Ahmed
到 2050 年，至少 7 亿人将需要听力治疗，而预计将有 25 亿人遭受听力损失。感音神经性听力损失 (SNHL) 是由于内耳无法将流体波转换为神经电信号而引起的，因为耳蜗毛细胞受到损伤并导致其死亡。此外，与其他病理有关的全身性慢性炎症可能会加剧细胞死亡，导致 SNHL。植物化学物质已成为一种可能的解决方案，因为越来越多的证据表明它们具有抗炎、抗氧化和抗凋亡特性。人参及其生物活性分子人参皂苷具有抑制促炎信号传导和防止细胞凋亡的作用。在当前的研究中，我们研究了人参皂苷 Rc (G-Rc) 对 UB/OC-2 原代小鼠感觉毛细胞存活响应棕榈酸酯诱导的损伤的影响。 G-Rc 促进 UB/OC-2 细胞存活和细胞周期进展。此外，G-Rc 还能增强 UB/OC-2 细胞向功能性感觉毛细胞的分化，并减轻棕榈酸诱导的炎症、内质网应激和细胞凋亡。目前的研究为 G-Rc 作为 SNHL 潜在佐剂的作用提供了新的见解，并值得进一步研究阐明分子机制。
By 2050, at least 700 million people will require hearing therapy while 2.5 billion are projected to suffer from hearing loss. Sensorineural hearing loss (SNHL) arises from the inability of the inner ear to convert fluid waves into neural electric signals because of injury to cochlear hair cells that has resulted in their death. In addition, systemic chronic inflammation implicated in other pathologies may exacerbate cell death leading to SNHL. Phytochemicals have emerged as a possible solution because of the growing evidence of their anti-inflammatory, antioxidant, and anti-apoptotic properties. Ginseng and its bioactive molecules, ginsenosides, exhibit effects that suppress pro-inflammatory signaling and protect against apoptosis. In the current study, we investigated the effects of ginsenoside Rc (G-Rc) on UB/OC-2 primary murine sensory hair cell survival in response to palmitate-induced injury. G-Rc promoted UB/OC-2 cell survival and cell cycle progression. Additionally, G-Rc enhanced the differentiation of UB/OC-2 cells into functional sensory hair cells and alleviated palmitate-induced inflammation, endoplasmic reticulum stress, and apoptosis. The current study offers novel insights into the effects of G-Rc as a potential adjuvant for SNHL and warrants further studies elucidating the molecular mechanisms.
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影响因子：
16.6
作者：
Back SH;Kaufman RJ
通讯作者：
Kaufman RJ
影响因子：
0.6
作者：
Mungan Durankaya S;Olgun Y;Aktaş S;Eskicioğlu HE;Gürkan S;Altun Z;Mutlu B;Kolatan E;Doğan E;Yılmaz O;Kırkım G
通讯作者：
Kırkım G
DOI：
10.1056/nejmra1616601
发表时间：
2017-12-21
期刊：
The New England journal of medicine
影响因子：
--
作者：
Cunningham LL;Tucci DL
通讯作者：
Tucci DL
影响因子：
5
作者：
de Kok, Theo M.;van Breda, Simone G.;Manson, Margaret M.
通讯作者：
Manson, Margaret M.
影响因子：
6.3
作者：
Choi, Min-Koo;Jin, Sojeong;Song, Im-Sook
通讯作者：
Song, Im-Sook