Traffic-related particulate matter and acute respiratory symptoms among New York City area adolescents.
Traffic-related particulate matter and acute respiratory symptoms among New York City area adolescents.
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DOI：
10.1289/ehp.0901499
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发表时间：
2010-09
影响因子：
10.4
通讯作者：
Kinney PL
中科院分区：
文献类型：
--
作者：
Patel MM;Chillrud SN;Correa JC;Hazi Y;Feinberg M;Kc D;Prakash S;Ross JM;Levy D;Kinney PL
暴露于与交通有关的颗粒物（PM）与儿童的不良呼吸健康结果有关。柴油机排气颗粒物（DEP）是城市细颗粒物[空气动力学直径≤ 2.5 μm（PM2.5）]的本地驱动因素;然而，将环境DEP暴露与急性呼吸道症状联系起来的证据相对较少，并且城市和哮喘儿童的易感性特征不充分。我们检查了纽约市（NYC）和附近郊区社区的哮喘和非哮喘青少年中每日环境黑碳（BC）浓度（一种DEP指标）与每日呼吸道症状的关联。在纽约市三所高中和一所郊区高中外连续监测BC和PM2.5 4-6周，并使用日记从249名受试者（57名哮喘患者，192名非哮喘患者）中获得每日症状数据。污染物和症状之间的关联的特点是使用多层次广义线性混合模型，并修改城市居住和哮喘状态进行了检查。BC增加与喘息、呼吸短促和胸闷增加相关。二氧化氮（NO2）暴露的多个滞后与症状有关。对于一些症状，与BC和NO2的关联在城市受试者和哮喘患者中分别显著大于郊区受试者和非哮喘患者。PM2.5与症状的增加并不总是相关。急性暴露于与交通有关的污染物，如DEPs和/或NO2，可能会导致青少年呼吸道疾病的发病率增加，城市居民和哮喘患者的风险可能会增加。这些发现为制定进一步减少柴油排放的额外策略提供了支持，特别是在因环境或潜在呼吸道疾病而易受影响的人群中。
Exposure to traffic-related particulate matter (PM) has been associated with adverse respiratory health outcomes in children. Diesel exhaust particles (DEPs) are a local driver of urban fine PM [aerodynamic diameter ≤ 2.5 μm (PM2.5)]; however, evidence linking ambient DEP exposure to acute respiratory symptoms is relatively sparse, and susceptibilities of urban and asthmatic children are inadequately characterized. We examined associations of daily ambient black carbon (BC) concentrations, a DEP indicator, with daily respiratory symptoms among asthmatic and nonasthmatic adolescents in New York City (NYC) and a nearby suburban community. BC and PM2.5 were monitored continuously outside three NYC high schools and one suburban high school for 4–6 weeks, and daily symptom data were obtained from 249 subjects (57 asthmatics, 192 nonasthmatics) using diaries. Associations between pollutants and symptoms were characterized using multilevel generalized linear mixed models, and modification by urban residence and asthma status were examined. Increases in BC were associated with increased wheeze, shortness of breath, and chest tightness. Multiple lags of nitrogen dioxide (NO2) exposure were associated with symptoms. For several symptoms, associations with BC and NO2 were significantly larger in magnitude among urban subjects and asthmatics compared with suburban subjects and nonasthmatics, respectively. PM2.5 was not consistently associated with increases in symptoms. Acute exposures to traffic-related pollutants such as DEPs and/or NO2 may contribute to increased respiratory morbidity among adolescents, and urban residents and asthmatics may be at increased risk. The findings provide support for developing additional strategies to reduce diesel emissions further, especially in populations susceptible because of environment or underlying respiratory disease.
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影响因子：
10.4
作者：
Koenig, J Q;Jansen, K;Mar, T F;Lumley, T;Kaufman, J;Trenga, C A;Sullivan, J;Liu, L-J S;Shapiro, G G;Larson, T V
通讯作者：
Larson, T V
影响因子：
10.4
作者：
Hirshon JM;Shardell M;Alles S;Powell JL;Squibb K;Ondov J;Blaisdell CJ
通讯作者：
Blaisdell CJ
影响因子：
4.9
作者：
Chang, J.;Delfino, R. J.;Cooper, D.
通讯作者：
Cooper, D.
影响因子：
11.4
作者：
Glaser, B;Dreyer, A;Heitmann, T
通讯作者：
Heitmann, T
影响因子：
5.6
作者：
Bömmel, H;Haake, M;Duschl, A
通讯作者：
Duschl, A