Elevated ambient air zinc increases pediatric asthma morbidity.
Elevated ambient air zinc increases pediatric asthma morbidity.
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DOI：
10.1289/ehp.10759
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发表时间：
2008-06
影响因子：
10.4
通讯作者：
Blaisdell CJ
中科院分区：
文献类型：
--
作者：
Hirshon JM;Shardell M;Alles S;Powell JL;Squibb K;Ondov J;Blaisdell CJ
最近的研究表明，细颗粒物[PM 空气动力学直径 (PM2.5) ≤ 2.5 μm] 的成分与心血管和呼吸系统疾病住院人数的增加有关。 PM2.5 的金属成分会影响过敏和/或炎症反应，而环境中的锌会导致易感成年人的肺功能恶化。然而，有关环境空气中锌水平与哮喘医疗保健利用之间关系的信息有限，尤其是儿童。我们的目的是调查室外环境空气 PM2.5 锌水平与居住在城市地区的儿童的紧急医疗保健利用之间的关系。我们使用时间序列研究来估计马里兰州巴尔的摩市环境空气 PM2.5 锌水平与儿童入院和急诊室 (ED) 使用率之间的关系，并控制了时间趋势。我们使用的数据来自 2002 年 6 月至 2002 年 11 月期间大巴尔的摩地区 0-17 岁儿童的 ED 日常出院管理索赔和哮喘住院治疗情况。我们在美国环境保护署资助的巴尔的摩超级站点项目期间收集了环境空气 PM2.5 金属浓度数据，通过 X 射线荧光光谱法测定。考虑到随时间变化的潜在混杂因素后，前一天的中等锌水平（8.63-20.76 ng/m3）与儿童哮喘急性发作的风险相关，比前一天低锌水平（< 8.63 ng/m3）的风险高出 1.23（95% 置信区间，1.07-1.41）倍。结果表明，环境空气 PM2.5 锌水平较高与居住在城市地区的儿童第二天因哮喘就诊/入院的次数增加有关。
Recent studies indicate that the composition of fine particulate matter [PM ≤ 2.5 μm in aerodynamic diameter (PM2.5)] is associated with increased hospitalizations for cardiovascular and respiratory diseases. The metal composition of PM2.5 influences allergic and/or inflammatory reactions, and ambient zinc contributes to worsening pulmonary function in susceptible adults. However, information is limited concerning associations between ambient air zinc levels and health care utilization for asthma, especially among children. We aimed to investigate the relationship between outdoor ambient air PM2.5 zinc levels and urgent health care utilization for children living in an urban area. We used a time-series study to estimate the association of ambient air PM2.5 zinc levels with hospital admissions and emergency department (ED) utilization by children in Baltimore, Maryland, controlling for time trends. We used data from daily discharge administrative claims of ED and hospital utilization for asthma in children, 0–17 years of age for Greater Baltimore from June 2002 through November 2002. We collected ambient air PM2.5 metal concentration data, determined by X-ray fluorescence spectroscopy, during the U.S. Environmental Protection Agency–sponsored Baltimore Supersite project. Previous-day medium levels of zinc (8.63–20.76 ng/m3) are associated with risks of pediatric asthma exacerbations that are 1.23 (95% confidence interval, 1.07–1.41) times higher than those with previous-day low levels of zinc (< 8.63 ng/m3) after accounting for time-varying potential confounders. Results suggest that high ambient air PM2.5 zinc levels are associated with an increase in ED visits/hospital admissions for asthma on the following day among children living in an urban area.
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影响因子：
5.9
作者：
Peden, DB
通讯作者：
Peden, DB
影响因子：
5
作者：
Ondov, J. M.;Buckley, T. J.;Wexler, A. S.
通讯作者：
Wexler, A. S.
影响因子：
10.4
作者：
Dye, JA;Lehmann, JR;Costa, DL
通讯作者：
Costa, DL
影响因子：
10.4
作者：
Peden DB
通讯作者：
Peden DB
环境PM2.5的金属组成会影响小鼠过敏性气道疾病的严重程度。
影响因子：
10.4
作者：
Gavett, Stephen H;Haykal-Coates, Najwa;Copeland, Lisa B;Heinrich, Joachim;Gilmour, M Ian
通讯作者：
Gilmour, M Ian