Simultaneous Intake of Euglena Gracilis and Vegetables Synergistically Exerts an Anti-Inflammatory Effect and Attenuates Visceral Fat Accumulation by Affecting Gut Microbiota in Mice.
Simultaneous Intake of Euglena Gracilis and Vegetables Synergistically Exerts an Anti-Inflammatory Effect and Attenuates Visceral Fat Accumulation by Affecting Gut Microbiota in Mice.
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DOI：
10.3390/nu10101417
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发表时间：
2018-10-03
期刊：
影响因子：
5.9
通讯作者：
Tsuduki T
中科院分区：
文献类型：
--
作者：
Sakanoi Y;E S;Yamamoto K;Ota T;Seki K;Imai M;Ota R;Asayama Y;Nakashima A;Suzuki K;Tsuduki T
我们确定了是否可以通过共同食用富含可溶性膳食纤维的蔬菜来增强食用纤细裸藻（Euglena gracilis）（裸藻是一种单细胞光合作用的绿色藻类，富含不溶性膳食纤维副淀粉）所提供的益处。将9周龄雄性C57 BL/6 J小鼠分为四组：第1组接受正常饮食，第2、3和4组分别接受含有0.3%草履虫、1.0%裸藻或1.0%裸藻加0.3%蔬菜（大麦叶、羽衣甘蓝和明日叶）的正常饮食。小鼠自由进食直至18周龄。裸藻摄入量显着降低血清炎症标志物和蔬菜的共同消费增强了这种减少。值得注意的是，我们观察到产生短链脂肪酸的有益细菌比例增加，导致炎症的有害细菌减少，短链脂肪酸产量增加。内脏脂肪积累也减少了。随后的分析表明，裸藻与蔬菜的共同消费减少了脂肪细胞面积，抑制了与脂肪酸合成相关的基因的表达，并增加了与脂肪细胞生长和脂解相关的基因的表达。因此，裸藻与蔬菜的共同消费增强了其抗炎作用和对内脏脂肪积累的抑制作用，可能是通过调节肠道微生物群的组成。
We determined whether the benefits provided by the consumption of Euglena gracilis (Euglena), which is a unicellular photosynthesizing green alga and rich in insoluble dietary fiber paramylon, can be enhanced by the co-consumption of vegetables that are rich in soluble dietary fiber. Nine-week-old male C57BL/6J mice were divided into four groups: group 1 received normal diet, whereas groups 2, 3 and 4 received normal diet containing 0.3% paramylon, 1.0% Euglena, or 1.0% Euglena plus 0.3% vegetables (barley leaf, kale and ashitaba), respectively. Mice were fed ad libitum until 18 weeks of age. Euglena intake significantly decreased serum markers of inflammation and co-consumption of vegetables enhanced this reduction. Notably, we observed an increase in the fraction of beneficial bacteria producing short-chain fatty acids, a reduction in harmful bacteria that cause inflammation and an increase in short-chain fatty acid production. Visceral fat accumulation was also reduced. Subsequent analyses showed that co-consumption of Euglena with vegetables reduced adipocyte area, suppressed the expression of genes related to fatty acid synthesis and increased the expression of genes related to adipocyte growth and lipolysis. Therefore, co-consumption of Euglena with vegetables enhanced its anti-inflammatory effect and the inhibitory effect on visceral fat accumulation likely by modulating the composition of gut microbiota.
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