Blood biomarkers to predict the onset of pre-eclampsia: A systematic review and meta-analysis.
Blood biomarkers to predict the onset of pre-eclampsia: A systematic review and meta-analysis.
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DOI：
10.1016/j.heliyon.2022.e11226
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发表时间：
2022-11
期刊：
影响因子：
4
通讯作者：
Tan, Bee Kang
中科院分区：
文献类型：
--
作者：
Danielli, Marianna;Thomas, Roisin C.;Gillies, Clare L.;Hu, Jiamiao;Khunti, Kamlesh;Tan, Bee Kang
先兆子痫是最常见的妊娠并发症之一，也是全球胎儿和孕产妇发病率和死亡率的主要原因。目前的诊断是在妊娠晚期根据临床症状进行的。这项系统性综述和荟萃分析旨在确定与先兆子痫相关的血液生物标志物，特别是可以预测妊娠早期先兆子痫的生物标志物。我们检索了从开始到2022年3月的电子数据库（Medline、Embase、科克伦图书馆）。这项系统性综述纳入了1000名或更多参与者的前瞻性研究，这些研究测量了血液生物标志物以预测或诊断先兆子痫。生物标志物的测量被认为是从第一个到第三个三个月，但不是在劳动。提取关于先兆子痫、生物标志物测量和研究特征的数据。尽可能进行Meta分析。我们发现共有43项研究（评估18，170例妊娠中的62种不同生物标志物）已纳入本系统性综述，共有6项研究（评估2种生物标志物）已纳入荟萃分析。对PlGF和sFlt-1进行统计分析。先兆子痫和健康妊娠之间PlGF水平的平均差异似乎随着妊娠进展而增加。sFlt-1荟萃分析的结果不确定。未发现显著的发表偏倚。这是关于早期预测先兆子痫的血液生物标志物这一重要主题的最全面和最新的系统综述和荟萃分析。这项研究强调了进一步发现研究的迫切需要，以确定可以预测先兆子痫发展的血液生物标志物。生物标志物;血液;妊娠;先兆子痫;早期预测。
Pre-eclampsia is one of the most common pregnancy complications, and a major cause of fetal and maternal morbidity and mortality globally. Diagnosis currently takes place in the third trimester based on clinical symptoms. This systematic review and meta-analysis sought to determine the blood biomarkers that are associated with pre-eclampsia, and in particular, the biomarkers that could predict pre-eclampsia in early pregnancy. We searched the electronic databases (Medline, Embase, Cochrane Library) from inception up to March 2022. Prospective studies with 1000 or more participants that measured blood biomarkers to predict or diagnose pre-eclampsia have been included in this systematic review. Biomarkers’ measurements were considered from the first up to the third trimester, but not during labor. Data concerning pre-eclampsia, biomarker measurements and study characteristics were extracted. Meta-analysis was performed when possible. We found a total of 43 studies (assessing 62 different biomarkers in 18,170 pregnancies, have been included in this systematic review, and a total of 6 studies (assessing 2 biomarkers have been included in the meta-analysis). Statistical analysis was performed for PlGF and sFlt-1. Mean difference in PlGF levels between pre-eclampsia and healthy pregnancies, appear to increase as the pregnancy progresses. Results of sFlt-1 meta-analysis were inconclusive. No significant publication bias was identified. This is the most comprehensive and up to date systematic review and meta-analysis on this important topic on blood biomarkers for the early prediction of pre-eclampsia. Further This research highlights the urgent needed for further discovery research to identify blood biomarkers that could predict the development of pre-eclampsia. Biomarkers; Blood; Pregnancy; Pre-eclampsia; Early prediction.
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