The Role of Leptin in Fetal Growth during Pre-Eclampsia.
The Role of Leptin in Fetal Growth during Pre-Eclampsia.
复制标题
瘦素在子痫前期胎儿生长发育中的作用
DOI：
10.3390/ijms22094569
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发表时间：
2021-04-27
影响因子：
5.6
通讯作者：
Lausten-Thomsen U
中科院分区：
文献类型：
--
作者：
de Knegt VE;Hedley PL;Kanters JK;Thagaard IN;Krebs L;Christiansen M;Lausten-Thomsen U
瘦素是由胎盘分泌的，在与妊娠相关的功能调节中具有多方面的作用。妊娠期间瘦素相关的代谢紊乱和体内平衡代偿机制不足在子痫前期（PE）的发展中起决定性作用，并导致宫内生长条件受损和后代出生体重异常。这篇综述是为了通过瘦素的检测来阐明PE的代谢背景及其与不良宫内生长条件的关系，并描述瘦素与胎儿生长限制的可能机制。这篇综述说明了瘦素在PE中在母体、胎儿和胎盘室中是失调的。在PE的范围内没有单一的统一机制，涉及瘦素的调节机制对每种情况都是特定的。我们的结论是，通过与平行妊娠系统的复杂相互作用，瘦素失调在许多层面上参与胎儿生长，并可能贯穿整个妊娠过程。
Leptin is secreted by the placenta and has a multi-facetted role in the regulation of functions related to pregnancy. Metabolic disorders and insufficient homeostatic compensatory mechanisms involving leptin during pregnancy play a decisive role in the development of pre-eclampsia (PE) and give rise to compromised intrauterine growth conditions and aberrant birth weight of offspring. This review was compiled to elucidate the metabolic background of PE and its relationship with adverse intrauterine growth conditions through the examination of leptin as well as to describe possible mechanisms linking leptin to fetal growth restriction. This review illustrates that leptin in PE is dysregulated in maternal, fetal, and placental compartments. There is no single set of unifying mechanisms within the spectrum of PE, and regulatory mechanisms involving leptin are specific to each situation. We conclude that dysregulated leptin is involved in fetal growth at many levels through complex interactions with parallel pregnancy systems and probably throughout the entirety of pregnancy.
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