Degradable porous carboxymethyl chitin hemostatic microspheres
Degradable porous carboxymethyl chitin hemostatic microspheres
复制标题
可降解多孔羧甲基甲壳素止血微球
DOI：
10.1080/09205063.2020.1760461
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发表时间：
2020-04
期刊：
影响因子：
--
通讯作者：
Jiang Xulin
中科院分区：
文献类型：
--
作者：
Zhao Yong;Li Jiazhen;Leng Fan;Lv Siyao;Huang Wei;Sun Weiqing;Jiang Xulin
摘要致命性出血可能危及生命。虽然目前已有多种止血药物上市，且临床效果良好，但开发高效、生物安全、低成本、易制备、生物降解性和生物相容性好的新型止血材料已成为当务之急。本文以低取代度、低脱乙酰度的热敏性羧甲基甲壳素(CMCH)为原料，在不使用任何有毒交联剂的情况下，在高温下进行物理交联，制备了具有规则球形结构和多孔结构的新型可生物降解微球。所制得的CMCH微球(CMCH-MS)无细胞毒性，溶血能力低，在溶菌酶存在下可生物降解。体外凝血实验表明，由于CMCH-MS的快速血液吸收和凝血因子的局部聚集，CMCH-MS的多孔微球网络结构和亲水性可以促进止血。在大鼠尾部和肝脏模型中，CMCH-MS的止血效果明显优于阴性对照和传统的壳聚糖止血，止血性能与商品化的交联型淀粉微球相近。因此，新型可生物降解的多孔CMCH-MS在医疗出血控制方面具有很大的潜力。图形摘要
Abstract Lethal hemorrhage could endanger lives. Although many hemostatic agents are commercially available with good clinical effect, it is necessary to develop novel hemostatic materials with high efficacy, biological safety, low cost, easily preparation and excellent biodegradability and biocompatibility. Here, novel biodegradable and uniform microspheres with regular spherical architecture and porous microstructure were prepared by thermosensitive carboxymethyl chitin (CMCH) with low substitution degree and low deacetylation through physical-crosslinking at high temperature without using any toxic crosslinkers. The obtained CMCH microspheres (CMCH-MS) were non-cytotoxic, low hemolytic potential and biodegradable in the presence of lysozyme. In vitro blood clotting evaluation indicated that the porous microsphere network structures and the hydrophilicity of the CMCH could promote hemostasis due to the quick blood absorption and local concentration of the coagulation factors for the CMCH-MS. The CMCH-MS showed much better hemorrhage control than negative control and traditional hemostatic chitosan, similar hemostatic performance as commercialized cross-linked starch microspheres in both rat tail and liver models. Thus, the new biodegradable porous CMCH-MS may hold great potential for hemorrhage control in medical treatment. GRAPHIC ABSTRACT
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影响因子：
2.9
作者：
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通讯作者：
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影响因子：
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作者：
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作者：
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DOI：
10.1080/09205063.2018.1485815
发表时间：
2019-03-04
影响因子：
3.6
作者：
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通讯作者：
Li, Can