Associations of objectively assessed physical activity and sedentary time with all-cause mortality in US adults: the NHANES study.
Associations of objectively assessed physical activity and sedentary time with all-cause mortality in US adults: the NHANES study.
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DOI：
10.1371/journal.pone.0119591
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发表时间：
2015
期刊：
影响因子：
3.7
通讯作者：
Leitzmann MF
中科院分区：
文献类型：
--
作者：
Schmid D;Ricci C;Leitzmann MF
久坐行为与死亡风险增加有关。这种增加的风险是否可以通过加强体育活动来抵消，还没有使用加速度测量数据进行检验。我们研究了久坐时间和体力活动与任何原因导致的死亡率之间的关系，使用加速度计数据对1677名50岁及以上的男性和女性进行了研究，这些人来自2003-2004年国家健康与营养调查（NHANES）周期，随访至2006年12月31日。在平均34.67个月和4,845.42人年的随访期间，发生112例死亡。在多变量Cox比例风险模型中，久坐时间越长（中位数≥8.60小时/天）与任何原因导致的死亡风险增加相关(相对风险(RR) = 2.03；95%置信区间(CI) = 1.09-3.81)。低水平的中高强度体力活动（<中位数6.60分钟/天）也与全因死亡风险增加有关（RR = 3.30; 95% CI = 1.33-8.17）。在综合分析中，久坐不动和低水平的中度到剧烈体育活动预示着全因死亡风险的显著升高。与低久坐时间和高强度体力活动的组合相比，低久坐时间和体力活动的死亡率为4.38 (95% CI = 1.26-15.16)，久坐时间和高体力活动的死亡率为2.79 (95% CI = 0.77-10.12)，久坐时间和低体力活动的死亡率为7.79 （95% CI = 2.26-26.82）。久坐时间与中高强度体力活动之间的相互作用项无统计学意义（p = 0.508）。久坐时间过长和中度至剧烈体力活动过少都是任何原因导致的早期死亡的有力且独立的预测因素。高体力活动水平是否能消除与久坐相关的全因死亡风险增加，还需要进一步调查。
Sedentary behavior is related to increased mortality risk. Whether such elevated risk can be offset by enhanced physical activity has not been examined using accelerometry data. We examined the relations of sedentary time and physical activity to mortality from any cause using accelerometry data among 1,677 women and men aged 50 years or older from the National Health and Nutrition Examination Survey (NHANES) 2003–2004 cycle with follow-up through December 31, 2006. During an average follow-up of 34.67 months and 4,845.42 person-years, 112 deaths occurred. In multivariate Cox proportional hazard models, greater sedentary time (≥ median of 8.60 hours/day) was associated with increased risk of mortality from any cause (relative risk (RR) = 2.03; 95% confidence interval (CI) = 1.09-3.81). Low level of moderate to vigorous physical activity (< median of 6.60 minutes/day) was also related to enhanced all-cause mortality risk (RR = 3.30; 95% CI = 1.33-8.17). In combined analyses, greater time spent sedentary and low levels of moderate to vigorous physical activity predicted a substantially elevated all-cause mortality risk. As compared with the combination of a low sedentary level and a high level of moderate to vigorous physical activity, the risks of mortality from all causes were 4.38 (95% CI = 1.26-15.16) for low levels of both sedentary time and physical activity, 2.79 (95% CI = 0.77-10.12) for greater time spent sedentary and high physical activity level, and 7.79 (95% CI = 2.26-26.82) for greater time spent sedentary and low physical activity level. The interaction term between sedentary time and moderate to vigorous physical activity was not statistically significant (p = 0.508). Both high levels of sedentary time and low levels of moderate to vigorous physical activity are strong and independent predictors of early death from any cause. Whether a high physical activity level removes the increased risk of all-cause mortality related to sedentariness requires further investigation.
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影响因子：
18.4
作者：
Chau, Josephine Y.;Grunseit, Anne;Van der Ploeg, Hidde P.
通讯作者：
Van der Ploeg, Hidde P.
DOI：
10.1097/00005768-199805000-00021
发表时间：
1998-05-01
期刊：
MEDICINE AND SCIENCE IN SPORTS AND EXERCISE
影响因子：
--
作者：
Freedson, PS;Melanson, E;Sirard, J
通讯作者：
Sirard, J
影响因子：
3.7
作者：
Chau JY;Grunseit AC;Chey T;Stamatakis E;Brown WJ;Matthews CE;Bauman AE;van der Ploeg HP
通讯作者：
van der Ploeg HP
影响因子：
4.1
作者：
Gennuso KP;Gangnon RE;Matthews CE;Thraen-Borowski KM;Colbert LH
通讯作者：
Colbert LH
影响因子：
7.7
作者：
Hamilton, Marc T.;Hamilton, Deborah G.;Zderic, Theodore W.
通讯作者：
Zderic, Theodore W.