angaGEDUCI: Anopheles gambiae gene expression database with integrated comparative algorithms for identifying conserved DNA motifs in promoter sequences.
angaGEDUCI: Anopheles gambiae gene expression database with integrated comparative algorithms for identifying conserved DNA motifs in promoter sequences.
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AngageDuci：具有综合比较算法的冈比亚基因表达数据库，用于鉴定启动子序列中保守的DNA基序。
DOI：
10.1186/1471-2164-7-116
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发表时间：
2006-05-17
期刊：
影响因子：
4.4
通讯作者：
James, Anthony A.
中科院分区：
文献类型：
--
作者：
Dissanayake, Sumudu N.;Marinotti, Osvaldo;Ribeiro, Jose Marcos C.;James, Anthony A.
冈比亚按蚊基因组的完整序列使得能够对这一人类疟疾主要媒介的基因表达和调控进行全基因组分析。这些调查产生了对有效方法对所产生的大量数据进行编目和分析的需求。将全基因组数据组织到一个统一的数据库中，使得有效识别基因表达的空间和时间模式成为可能，并且通过将这些发现与比较算法配对，可能提供一种工具来深入了解调节这些表达模式的分子机制。我们提供一个可公开访问的数据库和集成数据挖掘工具 angaGEDUCI，它统一了 1) An 中基因表达的阶段和组织特异性微阵列分析。冈比亚在不同发育阶段和血粉后的时间分离，2) 功能基因注释，3) 基因组序列数据，以及 4) 启动子序列比较算法。该数据库可用于研究在特定阶段、组织和感兴趣模式中表达的基因，并鉴定可能在此类表达调节中发挥作用的保守启动子序列基序。可以从地址访问该数据库。通过将基因表达、功能和序列数据与集成序列比较算法相结合，angaGEDUCI 简化了空间和时间模式查找，并提供了一种直接的方法来开发预测和设计实验，以评估如何在分子水平上控制基因表达。
The completed sequence of the Anopheles gambiae genome has enabled genome-wide analyses of gene expression and regulation in this principal vector of human malaria. These investigations have created a demand for efficient methods of cataloguing and analyzing the large quantities of data that have been produced. The organization of genome-wide data into one unified database makes possible the efficient identification of spatial and temporal patterns of gene expression, and by pairing these findings with comparative algorithms, may offer a tool to gain insight into the molecular mechanisms that regulate these expression patterns. We provide a publicly-accessible database and integrated data-mining tool, angaGEDUCI, that unifies 1) stage- and tissue-specific microarray analyses of gene expression in An. gambiae at different developmental stages and temporal separations following a bloodmeal, 2) functional gene annotation, 3) genomic sequence data, and 4) promoter sequence comparison algorithms. The database can be used to study genes expressed in particular stages, tissues, and patterns of interest, and to identify conserved promoter sequence motifs that may play a role in the regulation of such expression. The database is accessible from the address . By combining gene expression, function, and sequence data with integrated sequence comparison algorithms, angaGEDUCI streamlines spatial and temporal pattern-finding and produces a straightforward means of developing predictions and designing experiments to assess how gene expression may be controlled at the molecular level.
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影响因子：
22.7
作者：
BOYER, RS;MOORE, JS
通讯作者：
MOORE, JS
影响因子：
2.6
作者：
Marinotti, O;Nguyen, QK;Ribeiro, JMC
通讯作者：
Ribeiro, JMC
影响因子：
2.6
作者：
Marinotti, O;Calvo, E;James, AA
通讯作者：
James, AA
影响因子：
12.3
作者：
Li J;Riehle MM;Zhang Y;Xu J;Oduol F;Gomez SM;Eiglmeier K;Ueberheide BM;Shabanowitz J;Hunt DF;Ribeiro JM;Vernick KD
通讯作者：
Vernick KD
影响因子：
2.6
作者：
Ribeiro, JMC;Topalis, P;Louis, C
通讯作者：
Louis, C