A systematic review of CD14 and toll-like receptors in relation to asthma in Caucasian children.
A systematic review of CD14 and toll-like receptors in relation to asthma in Caucasian children.
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DOI：
10.1186/1710-1492-9-10
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发表时间：
2013-03-15
期刊：
影响因子：
--
通讯作者：
Jöbsis Q
中科院分区：
文献类型：
--
作者：
Klaassen EM;Thönissen BE;van Eys G;Dompeling E;Jöbsis Q
儿童哮喘的病因是复杂的。先天免疫系统免疫发育的早期功能障碍与环境因素结合可能引发哮喘。CD 14和Toll样受体是先天免疫系统的重要组成部分。本系统综述的目的是更好地了解CD 14和Toll样受体与高加索人儿童哮喘之间的关系。我们检索了PubMed和EMBASE的相关文章。共纳入44篇文章。所选研究的质量由前两位作者使用Newcastle-Ottawa质量评估量表进行独立评估。Toll样受体2、Toll样受体6、Toll样受体9和Toll样受体10似乎与高加索人的儿童哮喘有一定关联。CD 14与儿童哮喘相关的证据有限。总之，目前还没有令人信服的证据表明CD 14和Toll样受体在儿童哮喘中的作用。未来的研究应包括单倍型分析，并考虑到环境因素，以进一步阐明CD 14和Toll样受体在儿童哮喘中的作用。
The aetiology of childhood asthma is complex. An early dysfunction in the immunological development of the innate immune system in combination with environmental factors possibly triggers asthma. CD14 and toll-like receptors are important components of the innate immune system. The aim of this systematic review was to obtain a better insight into the relation between CD14 and toll-like receptors and childhood asthma in Caucasians. We searched PubMed and EMBASE for relevant articles. In total, 44 articles were included. The quality of the selected studies was independently assessed by the first two authors using the Newcastle-Ottawa quality assessment scale. Toll-like receptor 2, toll-like receptor 6, toll-like receptor 9, and toll-like receptor 10 appear to have some association with childhood asthma in Caucasians. The evidence for a relation of CD14 with childhood asthma is limited. In conclusion, there is no convincing evidence yet for a role of CD14 and toll-like receptors in relation to childhood asthma. Future studies should include haplotype analysis and take environmental factors into account to further clarify the role of CD14 and toll-like receptors on childhood asthma.
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影响因子：
14.2
作者：
Bieli, Christian;Eder, Waltraud;Martinez, Fernando D.
通讯作者：
Martinez, Fernando D.
影响因子：
14.2
作者：
Jones, CA;Holloway, JA;Warner, JO
通讯作者：
Warner, JO
影响因子：
5.3
作者：
Daley, Denise;Lemire, Mathieu;Hudson, Thomas J.
通讯作者：
Hudson, Thomas J.
DOI：
10.1164/rccm.200304-499oc
发表时间：
2004-01-01
影响因子：
24.7
作者：
Guerra, S;Lohman, IC;Wright, AL
通讯作者：
Wright, AL
影响因子：
5.8
作者：
Halfhide, Clare;Smyth, Rosalind L.
通讯作者：
Smyth, Rosalind L.