Ceramic Nanomaterials in Caries Prevention: A Narrative Review.
Ceramic Nanomaterials in Caries Prevention: A Narrative Review.
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陶瓷纳米材料在龋齿预防中的作用：叙述性回顾
DOI：
10.3390/nano12244416
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发表时间：
2022-12-11
期刊：
影响因子：
5.3
通讯作者：
Chu, Chun Hung
中科院分区：
文献类型：
--
作者：
Nizami, Mohammed Zahedul Islam;Xu, Veena Wenqing;Yin, Iris Xiaoxue;Lung, Christie Ying Kei;Niu, John Yun;Chu, Chun Hung
陶瓷纳米材料是纳米级无机类金属固体，可以通过在高温下加热然后快速冷却来合成。自20世纪80年代开发出第一种纳米铈以来，陶瓷纳米材料因其在应用和技术上的多功能性而迅速成为研究的核心纳米材料之一。研究人员正在开发牙科用陶瓷纳米材料，因为陶瓷纳米颗粒比金属纳米颗粒更稳定，生产成本更低。陶瓷纳米材料可用于预防龋齿，因为其中一些具有矿化特性，可促进牙齿组织的矿化。陶瓷矿物质促进矿化过程，并保持pH值平衡，以保持牙齿完整性。此外，陶瓷纳米材料具有抗菌性能，可抑制致龋生物膜的生长。研究人员已经开发出抗菌纳米颗粒，具有抗菌和矿化特性的共轭陶瓷矿物质，以防止龋齿的形成和发展。为预防龋齿而开发的常见陶瓷纳米材料包括钙基（包括羟基磷灰石基）、生物活性玻璃基和二氧化硅基纳米颗粒。钙基纳米陶瓷材料可以通过沉积钙离子来替代失去的羟基磷灰石。生物活性玻璃基纳米颗粒含有表面反应性玻璃，可以形成类似于骨骼和牙齿组织的磷灰石晶体，并与骨骼和牙齿组织形成化学键合。基于二氧化硅的纳米颗粒含有二氧化硅，用于胶原浸润和增强牙本质胶原基质的异质矿化。总之，陶瓷纳米材料可用于龋齿预防，因为它们具有抗菌和矿化特性。本研究概述了陶瓷纳米材料预防龋齿的研究进展。
Ceramic nanomaterials are nanoscale inorganic metalloid solids that can be synthesised by heating at high temperatures followed by rapid cooling. Since the first nanoceramics were developed in the 1980s, ceramic nanomaterials have rapidly become one of the core nanomaterials for research because of their versatility in application and use in technology. Researchers are developing ceramic nanomaterials for dental use because ceramic nanoparticles are more stable and cheaper in production than metallic nanoparticles. Ceramic nanomaterials can be used to prevent dental caries because some of them have mineralising properties to promote the remineralisation of tooth tissue. Ceramic minerals facilitate the remineralisation process and maintain an equilibrium in pH levels to maintain tooth integrity. In addition, ceramic nanomaterials have antibacterial properties to inhibit the growth of cariogenic biofilm. Researchers have developed antimicrobial nanoparticles, conjugated ceramic minerals with antibacterial and mineralising properties, to prevent the formation and progression of caries. Common ceramic nanomaterials developed for caries prevention include calcium-based (including hydroxyapatite-based), bioactive glass-based, and silica-based nanoparticles. Calcium-based ceramic nanomaterials can substitute for the lost hydroxyapatite by depositing calcium ions. Bioactive glass-based nanoparticles contain surface-reactive glass that can form apatite crystals resembling bone and tooth tissue and exhibit chemical bonding to the bone and tooth tissue. Silica-based nanoparticles contain silica for collagen infiltration and enhancing heterogeneous mineralisation of the dentin collagen matrix. In summary, ceramic nanomaterials can be used for caries prevention because of their antibacterial and mineralising properties. This study gives an overview of ceramic nanomaterials for the prevention of dental caries.
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