Lessons from Dairy Farmers for Occupational Allergy and Respiratory Disease.

Lessons from Dairy Farmers for Occupational Allergy and Respiratory Disease.
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奶农对职业性过敏和呼吸道疾病的教训。

DOI:
10.1007/s11882-023-01081-2
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发表时间:
2023-06
影响因子:
5.5
通讯作者:
Schaeffer, J. W.
Schaeffer, J. W.
中科院分区:
医学2区
文献类型:
--
作者:
Seidel, J.;Magzamen, S.;Wang, Y. H.;Neujahr, V.;Schaeffer, J. W.

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长期以来,在乳品厂接触生物气溶胶与过敏、呼吸道疾病和肺功能下降有关。暴露评估的最新进展有助于我们了解这些生物气溶胶的大小分布和组成,但仅关注暴露的调查可能会忽视影响工人对疾病易感性的重要内在因素。在我们的综述中,我们讨论了最新的研究,检查暴露和遗传因素,有助于职业病的乳品工作。我们还回顾了最近在畜牧业工作中与人畜共患病病原体,抗菌素耐药基因和人类微生物组的作用有关的问题。本综述中强调的研究表明,需要进一步研究,以更好地了解外在和内在因素,耐药基因,病毒病原体和人类微生物组背景下的生物气溶胶的呼吸-响应关系,以帮助提供有效的干预措施,改善奶农的呼吸系统健康。
Exposure to bioaerosols at dairies has long been associated with allergy, respiratory disease, and decreases in lung function. Recent advancements in exposure assessments have aided our understanding on the size distribution and composition of these bioaerosols, but investigations focusing solely on exposures may overlook important intrinsic factors impacting worker’s susceptibility to disease. In our review, we discuss the most recent studies examining the exposures and genetic factors that contribute to occupational disease in dairy work. We also review more recent concerns in livestock work associated with zoonotic pathogens, antimicrobial resistant genes, and the role of the human microbiome. The studies highlighted in this review demonstrate the need for further research to better understand bioaerosol exposure–response relationships in the context of extrinsic and intrinsic factors, antibiotic-resistant genes, viral pathogens, and the human microbiome to help inform effective interventions that improve respiratory health among dairy farmers.
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