Exfoliative toxins of Staphylococcus aureus.
Exfoliative toxins of Staphylococcus aureus.
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作者：
Bukowski M;Wladyka B;Dubin G
金黄色葡萄球菌（Staphylococcus aureus）是人畜共患的重要病原菌。它会引起各种疾病，从相对无害的局部皮肤感染到危及生命的全身性疾病。在多种毒力因子中，葡萄球菌分泌的几种外毒素与特定的疾病症状直接相关。这些包括中毒性休克综合征毒素1（TSST-1）、肠毒素和剥脱性毒素（ESTs）。后者作为葡萄球菌烫伤样皮肤综合征（SSSS）的唯一病原体特别令人感兴趣，SSSS是一种主要影响婴儿的疾病，其特征是浅表皮肤层的丧失、脱水和继发感染。SSSS的临床症状的分子基础是很好的理解。丝氨酸蛋白酶是具有高底物特异性的丝氨酸蛋白酶，其选择性地识别并水解皮肤中的桥粒蛋白。本文综述了导致SSSS的药物的发现及其作用机制的研究进展。
Staphylococcus aureus is an important pathogen of humans and livestock. It causes a diverse array of diseases, ranging from relatively harmless localized skin infections to life-threatening systemic conditions. Among multiple virulence factors, staphylococci secrete several exotoxins directly associated with particular disease symptoms. These include toxic shock syndrome toxin 1 (TSST-1), enterotoxins, and exfoliative toxins (ETs). The latter are particularly interesting as the sole agents responsible for staphylococcal scalded skin syndrome (SSSS), a disease predominantly affecting infants and characterized by the loss of superficial skin layers, dehydration, and secondary infections. The molecular basis of the clinical symptoms of SSSS is well understood. ETs are serine proteases with high substrate specificity, which selectively recognize and hydrolyze desmosomal proteins in the skin. The fascinating road leading to the discovery of ETs as the agents responsible for SSSS and the characterization of the molecular mechanism of their action, including recent advances in the field, are reviewed in this article.
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影响因子：
6.5
作者：
Amagai, M;Yamaguchi, T;Stanley, JR
通讯作者：
Stanley, JR
影响因子：
2.1
作者：
Futagawa-Saito, Keiko;Makino, Shinichiroh;Fukuyasu, Tsuguaki
通讯作者：
Fukuyasu, Tsuguaki
影响因子：
3.1
作者：
DIMOND, RL;WUEPPER, KD
通讯作者：
WUEPPER, KD
影响因子：
3.2
作者：
Ahrens, P;Andresen, LO
通讯作者：
Andresen, LO
影响因子：
3.3
作者：
Andresen, LO;Ahrens, P;Bille-Hansen, V
通讯作者：
Bille-Hansen, V