Changes in Dietary Inflammatory Index Score over Time and Cancer Development in Rural Post-Menopausal Women.
Changes in Dietary Inflammatory Index Score over Time and Cancer Development in Rural Post-Menopausal Women.
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DOI：
10.3390/antiox12040946
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发表时间：
2023-04-18
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影响因子：
--
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中科院分区：
文献类型：
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炎症在癌症发展中起着关键作用。作为炎症的重要调节剂，饮食的作用应加以探讨。本研究的目的是确定具有较高炎症潜力的饮食（通过饮食炎症指数（DII®）测量）与农村绝经后妇女队列中癌症发展之间的关联。来自内布拉斯加州农村绝经后妇女的随机对照试验队列的饮食摄入量用于计算基线和4年后（访视9）的能量调整DII（E-DIITM）评分。线性混合模型分析和多变量逻辑回归评价了E-DII评分（基线、访视9、变化评分）与癌症状态之间的相关性。在1977名合格参与者中，患癌症的受试者（n = 91，4.6%）的E-DII评分的促炎性变化显著更大（非癌症：Δ 0.19 ± 1.43 vs.癌症：Δ 0.55 ± 1.43，p = 0.02）。调整后，E-DII评分变化较大（更多促炎性）的患者发生癌症的几率比E-DII变化较小的患者高20%以上（OR = 1.21，95% CI [1.02，1.42]，p = 0.02）。在四年内转向更促炎的饮食模式与癌症发展的几率增加有关，但与基线或单独访视9时的E-DII无关。
Inflammation plays a key role in cancer development. As an important modulator of inflammation, the role of diet should be explored. The purpose of this study was to determine the association between diets with a higher inflammatory potential, as measured by the Dietary Inflammatory Index (DII®), and cancer development in a cohort of rural post-menopausal women. Dietary intake from a randomized controlled trial cohort of rural, post-menopausal women in Nebraska was used to compute energy-adjusted DII (E-DIITM) scores at baseline and four years later (visit 9). A linear mixed model analysis and multivariate logistic regression evaluated the association between E-DII scores (baseline, visit 9, change score) and cancer status. Of 1977 eligible participants, those who developed cancer (n = 91, 4.6%) had a significantly larger, pro-inflammatory change in E-DII scores (Non-cancer: Δ 0.19 ± 1.43 vs. Cancer: Δ 0.55 ± 1.43, p = 0.02). After adjustment, odds of cancer development were over 20% higher in those with a larger change (more pro-inflammatory) in E-DII scores than those with smaller E-DII changes (OR = 1.21, 95% CI [1.02, 1.42], p = 0.02). Shifting to a more pro-inflammatory diet pattern over four years was associated with increased odds of cancer development, but not with E-DII at baseline or visit 9 alone.
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影响因子：
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作者：
Fan Y;Jin X;Man C;Gao Z;Wang X
通讯作者：
Wang X
DOI：
10.1136/bmj.d6617
发表时间：
2011-11-10
期刊：
BMJ (Clinical research ed.)
影响因子：
--
作者：
Aune D;Chan DS;Lau R;Vieira R;Greenwood DC;Kampman E;Norat T
通讯作者：
Norat T
影响因子：
3.5
作者：
通讯作者：
--
影响因子：
4.7
作者：
Ebert, MN;Klinder, A;Pool-Zobel, BL
通讯作者：
Pool-Zobel, BL
影响因子：
9.3
作者：
Hebert, James R.;Shivappa, Nitin;Hurley, Thomas G.
通讯作者：
Hurley, Thomas G.