Subthalamic nucleus--sensorimotor cortex functional connectivity in de novo and moderate Parkinson's disease.
Subthalamic nucleus--sensorimotor cortex functional connectivity in de novo and moderate Parkinson's disease.
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DOI：
10.1016/j.neurobiolaging.2014.07.004
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发表时间：
2015-01
影响因子：
4.2
通讯作者：
Vaillancourt DE
中科院分区：
文献类型：
--
作者：
Kurani AS;Seidler RD;Burciu RG;Comella CL;Corcos DM;Okun MS;MacKinnon CD;Vaillancourt DE
Previous research has indicated increased functional connectivity between subthalamic nucleus (STN) and sensorimotor cortex in off-medication Parkinson’s disease (PD) compared with control subjects. It is not clear if the increase in functional connectivity between STN and sensorimotor cortex occurs in de novo PD, which is prior to when patients begin dopamine therapy. Resting state functional magnetic resonance imaging was carried out in 20 de novo (drug-naïve) patients with PD (HY stage: I-II), 19 patients with moderate PD (HY stage: II-III), and 19 healthy controls. The functional connectivity analysis in de novo and moderate PD patients focused on the connectivity of the more affected STN and the sensorimotor cortex. Using resting state functional connectivity analysis, we provide new evidence that people with de novo PD and off-medicated moderate PD have increased functional connectivity between the more affected STN and different regions within the sensorimotor cortex. The overlapping sensorimotor cortex found in both de novo and moderate PD had functional connectivity values that correlated positively with the Unified Parkinson’s Disease Rating Scale part III. This key finding suggests that changes in functional connectivity between STN and sensorimotor cortex occur early in the disease following diagnosis and prior to dopamine therapy.
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发表时间：
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影响因子：
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