Active Sleep Promotes Functional Connectivity in Developing Sensorimotor Networks.

Active Sleep Promotes Functional Connectivity in Developing Sensorimotor Networks.
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DOI:
10.1002/bies.201700234
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发表时间:
2018-04
期刊:
BioEssays : news and reviews in molecular, cellular and developmental biology
影响因子:
--
通讯作者:
Blumberg MS
Blumberg MS
中科院分区:
其他
文献类型:
--
作者:
Del Rio-Bermudez C;Blumberg MS

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在哺乳动物和鸟类中普遍存在的主动(REM)睡眠特征是其在早期发育中的相对丰富。在出生后前两周的幼鼠中,主动睡眠促进皮质和皮质下感觉运动结构内和之间的同步振荡活动的表达。来自自发肌阵挛性抽搐的感觉反馈--这种抽搐只在活跃睡眠中产生--也会触发这些结构中的神经振荡。我们已经提出,婴儿早期活跃睡眠的功能之一是为同步发育结构提供背景。具体而言,神经振荡有助于各种神经发育过程,包括突触形成、神经元分化和迁移、凋亡以及地形图的细化。此外,同步振荡促进了遥远的大脑区域之间的功能连接。因此,任何限制主动睡眠的条件或操作都可能反过来剥夺婴儿动物的实质性感官体验,导致非典型的发育轨迹。
A ubiquitous feature of active (REM) sleep in mammals and birds is its relative abundance in early development. In rat pups across the first two postnatal weeks, active sleep promotes the expression of synchronized oscillatory activity within and between cortical and subcortical sensorimotor structures. Sensory feedback from self-generated myoclonic twitches—which are produced exclusively during active sleep—also triggers neural oscillations in those structures. We have proposed that one of the functions of active sleep in early infancy is to provide a context for synchronizing developing structures. Specifically, neural oscillations contribute to a variety of neurodevelopmental processes, including synapse formation, neuronal differentiation and migration, apoptosis, and the refinement of topographic maps. In addition, synchronized oscillations promote functional connectivity between distant brain areas. Consequently, any condition or manipulation that restricts active sleep can, in turn, deprive the infant animal of substantial sensory experience, resulting in atypical developmental trajectories.
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