Active Sleep Promotes Functional Connectivity in Developing Sensorimotor Networks.
Active Sleep Promotes Functional Connectivity in Developing Sensorimotor Networks.
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DOI:
10.1002/bies.201700234
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发表时间:
2018-04
期刊:
影响因子:
--
通讯作者:
Blumberg MS
中科院分区:
文献类型:
--
作者:
Del Rio-Bermudez C;Blumberg MS
A ubiquitous feature of active (REM) sleep in mammals and birds is its relative abundance in early development. In rat pups across the first two postnatal weeks, active sleep promotes the expression of synchronized oscillatory activity within and between cortical and subcortical sensorimotor structures. Sensory feedback from self-generated myoclonic twitches—which are produced exclusively during active sleep—also triggers neural oscillations in those structures. We have proposed that one of the functions of active sleep in early infancy is to provide a context for synchronizing developing structures. Specifically, neural oscillations contribute to a variety of neurodevelopmental processes, including synapse formation, neuronal differentiation and migration, apoptosis, and the refinement of topographic maps. In addition, synchronized oscillations promote functional connectivity between distant brain areas. Consequently, any condition or manipulation that restricts active sleep can, in turn, deprive the infant animal of substantial sensory experience, resulting in atypical developmental trajectories.
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影响因子:
16.6
作者:
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通讯作者:
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影响因子:
9.2
作者:
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通讯作者:
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影响因子:
9.2
作者:
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影响因子:
4.7
作者:
Daoust, AM;Limoges, T;Godbout, R
通讯作者:
Godbout, R
DOI:
10.1111/j.1460-9568.2012.08075.x
发表时间:
2012-05
期刊:
The European journal of neuroscience
影响因子:
--
作者:
Erzurumlu RS;Gaspar P
通讯作者:
Gaspar P