LDHC: the ultimate testis-specific gene.
LDHC: the ultimate testis-specific gene.
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DOI：
10.2164/jandrol.109.008367
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发表时间：
2010-01
影响因子：
--
通讯作者：
Odet F
中科院分区：
文献类型：
--
作者：
Goldberg E;Eddy EM;Duan C;Odet F
乳酸脱氢酶C（LDHC）是第一个在雄性生殖细胞中发现的睾丸特异性同工酶。事实上，这是在“同工酶或同工酶”成为一个研究领域之前不久完成的。用凝胶电泳法首次在人精子和睾丸生精细胞中检测到LDHC。免疫组化被用来本地化LDHC首先在粗线期初级精母细胞减数分裂后的数量明显增加，其最终定位在精子尾部的主要部分。经过几十年的生物学、生物化学和遗传学研究，我们现在知道乳酸脱氢酶同工酶在脊椎动物中普遍存在，具有发育调节、组织和细胞特异性和多功能性。在这里，我们将回顾LDHC的历史以及清楚地表明精子需要它来实现其最终目标--受精的工作。
Lactate dehydrogenase C (LDHC) was, to the best of our knowledge, the first testis specific isozyme discovered in male germ cells. In fact, this was accomplished shortly before “Isozymes or isoenzymes” became a field of study. LDHC was detected initially in human spermatozoa and spermatogenic cells of the testes by gel electrophoresis. Immunohistochemistry was used to localize LDHC first in early pachytene primary spermatocytes with an apparent increase in quantity following meiosis to its final localization in and on the principle piece of the sperm tail. After several decades of biological, biochemical and genetic investigations we now know that the lactate dehydrogenase isozymes are ubiquitous in vertebrates, developmentally regulated, tissue and cell specific and multi-functional. Here we will review the history of LDHC and the work that demonstrates clearly that it is required for sperm to accomplish their ultimate goal, fertilization.
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影响因子：
2.9
作者：
Goldberg, E;VandeBerg, JL;Doncel, GF
通讯作者：
Doncel, GF
影响因子：
--
作者：
GOLDBERG, E;HAWTREY, C
通讯作者：
HAWTREY, C
影响因子：
3.9
作者：
GOLDBERG, E
通讯作者：
GOLDBERG, E
影响因子：
2.5
作者：
FUJIMOTO H;ERICKSON R P;TONE S
通讯作者：
TONE S
影响因子：
3.6
作者：
BURGOS, C;MALDONADO, C;BLANCO, A
通讯作者：
BLANCO, A