Vitamin D deficiency and benign paroxysmal positioning vertigo.
Vitamin D deficiency and benign paroxysmal positioning vertigo.
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DOI：
10.1016/j.mehy.2012.11.029
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发表时间：
2013-02
影响因子：
4.7
通讯作者：
Lundberg, Yunxia Wang
中科院分区：
文献类型：
--
作者：
Bueki, Bela;Ecker, Michael;Juenger, Heinz;Lundberg, Yunxia Wang
良性阵发性位置性眩晕是致残性眩晕的常见原因，复发率高。虽然文献中分别提出了维生素D缺乏与骨质疏松症以及骨质疏松症与良性阵发性位置性眩晕之间的联系，但我们还没有发现任何文献将维生素D与良性阵发性位置性眩晕联系起来。作为一种假设，我们认为维生素D水平不足与良性阵发性位置性眩晕有关。为了验证这一假设，在一项小型的回溯性初步研究中，对良性阵发性位置性眩晕患者的血清25-羟基维生素D水平和纠正血清水平后的复发频率进行了回溯性评估。特发性位置性眩晕患者的血清25-羟基维生素D平均水平较低(23 ng/ml)，与奥地利普通人群相似，后者维生素D缺乏症的患病率较高。在4例慢性反复发作的重度眩晕患者中，血清25-羟基维生素D的平均水平甚至显著低于其他首发眩晕患者。补充维生素D后眩晕发作没有复发。我们提出了补充维生素D水平低的良性阵发性位置性眩晕患者从补充维生素D中受益的可能性，并建议进行进一步的流行病学调查，以确定纠正维生素D缺乏对眩晕复发的影响。鉴于维生素D的许多已知益处，作者建议在良性阵发性位置性眩晕患者中测量维生素D，并在必要时补充维生素D。
Benign paroxysmal positional vertigo is a common cause of disabling vertigo with a high rate of recurrence. Although connections between vitamin D deficiency and osteoporosis, as well as between osteoporosis and benign paroxysmal positional vertigo have been suggested respectively in the literature, we are not aware of any publication linking vitamin D and benign paroxysmal positional vertigo. As a hypothesis, we suggest that there is a relation between insufficient vitamin D level and benign paroxysmal positional vertigo. In order to test this hypothesis, in a small retrospective pilot study, 25-hydroxyvitamin D levels in serum of patients with benign paroxysmal positional vertigo and frequency of recurrence after correction of serum level were assessed retrospectively. Patients with idiopathic positional vertigo had a low average serum level of 25-hydroxyvitamin D (23 ng/mL) similar to that of the general Austrian population, which has a high prevalence of hypovitaminosis D. In 4 cases with chronically recurrent severe vertigo episodes, average levels of serum 25-hydroxyvitamin D were even significantly lower than in the other vertigo patients, who had their first episode. Vertigo attacks did not recur after supplementation with vitamin D. We raise the possibility that patients with benign paroxysmal positional vertigo who have low vitamin D levels may benefit from supplementation and suggest further epidemiological investigations to determine the effect of correcting vitamin D deficiency on the recurrence of vertigo. Given the many known benefits of vitamin D, the authors recommend the measurement of vitamin D in patients with benign paroxysmal positional vertigo and supplementation if necessary.
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