Malignant melanoma, breast cancer and other cancers in patients with Parkinson's disease.
Malignant melanoma, breast cancer and other cancers in patients with Parkinson's disease.
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DOI：
10.1002/ijc.27443
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发表时间：
2012-10-15
影响因子：
6.4
通讯作者：
Olsen, Jorgen H.
中科院分区：
文献类型：
--
作者：
Rugbjerg, Kathrine;Friis, Soren;Lassen, Christina Funch;Ritz, Beate;Olsen, Jorgen H.
先前的研究报告了帕金森病患者的非典型癌症模式。在这里，我们评估了在我们以前的队列研究的扩展中诊断为帕金森病的人的癌症模式。在这项基于丹麦人群的队列研究中，我们从丹麦国家医院登记处确定了1977-2006年诊断为帕金森病的20，000人。队列成员在丹麦癌症登记处接受癌症随访，直至2008年12月31日，并将其癌症发病率与一般人群的年龄、性别和日历期特异性发病率进行比较，作为标准化发病率比（SIR）。在亚组分析中，我们估计了早发性帕金森病患者的癌症风险，并将帕金森病女性患者的乳腺肿瘤特征与对照组进行了比较。在我们的队列中，总体癌症风险降低[SIR = 0.86; 95%置信区间（CI）= 0.83-0.90]，与吸烟相关（SIR = 0.65; 95% CI = 0.60-0.70）和非吸烟相关癌症（SIR = 0.79; 95% CI = 0.71-0.86）的风险也降低。该队列的恶性黑色素瘤（SIR = 1.41; 95% CI = 1.09-1.80）、非黑色素瘤皮肤癌（SIR = 1.29; 95% CI = 1.18-1.39）和女性乳腺癌（SIR = 1.17; 95% CI = 1.02-1.34）风险增加。在早发性帕金森病患者中，患癌症的风险与普通人群相当。在乳腺肿瘤的特征中，只有恶性程度在帕金森病患者和对照组之间存在差异。这项研究证实了帕金森病患者患癌症的风险较低。恶性黑色素瘤、非黑色素瘤皮肤癌和乳腺癌的风险增加可能是由于与帕金森病有共同的风险因素。
Previous studies report an atypical cancer pattern among patients with Parkinson’s disease. Here, we evaluate the cancer pattern among people diagnosed with Parkinson’s disease in an extension of our previous cohort study. For this Danish population-based cohort study, we identified 20,000 people with Parkinson’s disease diagnosed in 1977–2006, from the National Danish Hospital Register. Cohort members were followed up for cancer in the Danish Cancer Registry until December 31, 2008, and their incidence rates of cancer were compared to age-, sex- and calendar period-specific rates in the general population as standardized incidence rate ratios (SIRs). In subanalyses, we estimated the risk for cancer among patients with early onset Parkinson’s disease and we also compared breast tumor characteristics among women with Parkinson’s disease to that of a control group. The overall cancer risk in our cohort was decreased [SIR = 0.86; 95% confidence interval (CI) = 0.83–0.90], as were those for smoking-related (SIR = 0.65; 95% CI = 0.60–0.70) and nonsmoking-related cancers (SIR = 0.79; 95% CI = 0.71–0.86). The cohort had increased risks for malignant melanoma (SIR = 1.41; 95% CI = 1.09–1.80), nonmelanoma skin cancer (SIR = 1.29; 95% CI = 1.18–1.39) and female breast cancer (SIR = 1.17; 95% CI = 1.02–1.34). Among patients with early onset Parkinson’s disease, the risk for cancer was comparable to that of the general population. Of breast tumor characteristics, only grade of malignancy differed between Parkinson’s disease women and controls. This study confirms a lower cancer risk among people with Parkinson’s disease. Increased risks for malignant melanoma, nonmelanoma skin cancer and breast cancer might be due to shared risk factors with Parkinson’s disease.
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影响因子：
8.6
作者：
D'Amelio, M;Ragonese, P;Savettieri, G
通讯作者：
Savettieri, G
影响因子：
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