Alterations in oral bacterial communities are associated with risk factors for oral and oropharyngeal cancer.
Alterations in oral bacterial communities are associated with risk factors for oral and oropharyngeal cancer.
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DOI：
10.1038/s41598-017-17795-z
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发表时间：
2017-12-15
影响因子：
4.6
通讯作者：
Huttenhower C
中科院分区：
文献类型：
--
作者：
Börnigen D;Ren B;Pickard R;Li J;Ozer E;Hartmann EM;Xiao W;Tickle T;Rider J;Gevers D;Franzosa EA;Davey ME;Gillison ML;Huttenhower C
口腔鳞状细胞癌是发病率和死亡率的主要原因，吸烟、饮酒和口腔卫生不良是确定的危险因素。到目前为止，还没有大规模的病例对照研究考虑这些风险因素对口腔微生物组组成的影响，也没有微生物群落与口腔癌的关联。我们使用宏基因组多变量分析管道比较了121名口腔癌患者与242名年龄和性别匹配的对照组的口腔微生物组的组成，多样性和功能。在口腔卫生不良、吸烟和口腔癌的情况下，观察到口腔微生物组的组成和功能发生了显著变化。具体来说，我们观察到牙齿脱落后社区组成和功能发生了显着变化，目前吸烟者的变化较小，牙周炎患者抗氧化剂的产生增加，口腔癌患者谷氨酸代谢金属转运显着减少。虽然口腔癌患者的口腔微生物组的变化是显着的，但相对于牙齿脱落后的微生物组变化，它们的效应大小要低得多。牙齿脱落后的改变本身就是口腔癌的一个主要风险因素，可能是由于栖息地丧失造成的严重生态破坏的结果，但也可能有助于疾病的发展。
Oral squamous cell carcinomas are a major cause of morbidity and mortality, and tobacco usage, alcohol consumption, and poor oral hygiene are established risk factors. To date, no large-scale case-control studies have considered the effects of these risk factors on the composition of the oral microbiome, nor microbial community associations with oral cancer. We compared the composition, diversity, and function of the oral microbiomes of 121 oral cancer patients to 242 age- and gender-matched controls using a metagenomic multivariate analysis pipeline. Significant shifts in composition and function of the oral microbiome were observed with poor oral hygiene, tobacco smoking, and oral cancer. Specifically, we observed dramatically altered community composition and function after tooth loss, with smaller alterations in current tobacco smokers, increased production of antioxidants in individuals with periodontitis, and significantly decreased glutamate metabolism metal transport in oral cancer patients. Although the alterations in the oral microbiome of oral cancer patients were significant, they were of substantially lower effect size relative to microbiome shifts after tooth loss. Alterations following tooth loss, itself a major risk factor for oral cancer, are likely a result of severe ecological disruption due to habitat loss but may also contribute to the development of the disease.
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DOI：
10.1038/ismej.2012.8
发表时间：
2012-08
期刊：
The ISME journal
影响因子：
--
作者：
通讯作者：
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古巴口腔癌和Oo-pharynx癌症的危险因素。
影响因子：
8.8
作者：
Garrote, LF;Herrero, R;Reyes, RMO;Vaccarella, S;Anta, JL;Ferbeye, L;Muñoz, N;Franceschi, S
通讯作者：
Franceschi, S
影响因子：
3.7
作者：
Ahn J;Yang L;Paster BJ;Ganly I;Morris L;Pei Z;Hayes RB
通讯作者：
Hayes RB
DOI：
10.1038/ismej.2010.30
发表时间：
2010-08
期刊：
The ISME journal
影响因子：
--
作者：
通讯作者：
--
影响因子：
2.3
作者：
Divaris, Kimon;Olshan, Andrew F.;Smith, Joanna;Bell, Mary E.;Weissler, Mark C.;Funkhouser, William K.;Bradshaw, Patrick T.
通讯作者：
Bradshaw, Patrick T.