Poor glycemic control rather than types of diabetes is a risk factor for sarcopenia in diabetes mellitus: The MUSCLES-DM study.
Poor glycemic control rather than types of diabetes is a risk factor for sarcopenia in diabetes mellitus: The MUSCLES-DM study.
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DOI：
10.1111/jdi.13882
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发表时间：
2022-11
影响因子：
3.2
通讯作者：
中科院分区：
文献类型：
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虽然据报道血糖控制不良和胰岛素治疗与2型糖尿病的肌肉减少症有关，但1型糖尿病可能是肌肉减少症的更大风险。因此，我们研究了糖尿病类型、血糖控制和胰岛素治疗对肌肉减少症患病率和特征的影响。本研究共入组了812例日本糖尿病患者（1型：n = 57; 2型：n = 755）。肌肉减少症定义为握力低或步行速度慢和四肢骨骼肌质量低。在年龄≥65岁的参与者中，1型糖尿病患者的肌肉减少症患病率（20.0%）高于2型糖尿病患者（8.1%）。1型糖尿病患者手握力低下的发生率（50.0%）高于2型糖尿病患者（28.7%）。Logistic回归分析显示，1型糖尿病与低握力患病率显著相关。在逻辑回归分析中，胰岛素治疗与肌肉减少症的患病率显着相关;在调整HbA 1c后，这种关联并未保留。老年1型糖尿病患者肌肉减少症的患病率高于2型糖尿病患者。在肌肉减少症的组成部分中，差异最突出的是低握力的频率。血糖控制不佳而不是糖尿病类型或胰岛素治疗被认为是糖尿病患者肌肉减少症的主要危险因素。我们发现老年1型糖尿病患者肌肉减少症的患病率高于2型糖尿病患者。血糖控制不佳而不是糖尿病类型或胰岛素治疗被认为是糖尿病患者肌肉减少症的主要危险因素。需要进行一项纵向研究，以澄清1型糖尿病是否仍然是血糖控制良好的患者肌肉减少症的危险因素。
Though poor glycemic control and insulin treatment are reported to be associated with sarcopenia in type 2 diabetes, type 1 diabetes may be a stronger risk for sarcopenia. We therefore studied the effect of the type of diabetes, glycemic control, and insulin therapy on the prevalence and characteristics of sarcopenia. A total of 812 Japanese patients with diabetes (type 1: n = 57; type 2: n = 755) were enrolled in this study. Sarcopenia was defined as low handgrip strength or slow gait speed and low appendicular skeletal muscle mass. Among participants aged ≥65 years, the sarcopenia prevalence rate was higher among patients with type 1 diabetes (20.0%) than among those with type 2 diabetes (8.1%). The prevalence rate of low handgrip strength was higher in type 1 diabetes (50.0%) than in type 2 diabetes (28.7%). In logistic regression analysis, type 1 diabetes was significantly associated with the prevalence of low handgrip strength. In logistic regression analysis, medication with insulin was significantly associated with the prevalence of sarcopenia; this association was not retained after adjusting for HbA1c. The prevalence of sarcopenia in older adult patients was higher in those with type 1 diabetes than in those with type 2 diabetes. Among the components of sarcopenia, the difference was most prominent in the frequency of low handgrip strength. Poor glycemic control rather than type of diabetes or insulin treatment was revealed to be a primary risk factor for sarcopenia in diabetes mellitus. We found higher prevalence of sarcopenia in older adults with type 1 diabetes than in type 2 diabetes. Poor glycemic control rather than types of diabetes or insulin treatment was revealed to be a primary risk factor for sarcopenia in diabetes mellitus. A longitudinal study is needed to clarify whether type 1 diabetes mellitus remains as a risk factor for sarcopenia in patients with adequate glycemic control.
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影响因子：
3.2
作者：
Mori H;Kuroda A;Yoshida S;Yasuda T;Umayahara Y;Shimizu S;Ryomoto K;Yoshiuchi K;Yamamoto T;Matsuoka TA;Shimomura I;Matsuhisa M
通讯作者：
Matsuhisa M
影响因子：
4.2
作者：
Bouchi R;Fukuda T;Takeuchi T;Nakano Y;Murakami M;Minami I;Izumiyama H;Hashimoto K;Yoshimoto T;Ogawa Y
通讯作者：
Ogawa Y
影响因子：
82.9
作者：
Mandavilli, A;Cyranoski, D
通讯作者：
Cyranoski, D
DOI：
10.1067/mlc.2001.113504
发表时间：
2001-04-01
期刊：
JOURNAL OF LABORATORY AND CLINICAL MEDICINE
影响因子：
--
作者：
Morley, JE;Baumgartner, RN;Nair, KS
通讯作者：
Nair, KS
影响因子：
5.1
作者：
Fukushima, M;Suzuki, H;Seino, Y
通讯作者：
Seino, Y