Inhalant and Additional Mucosal-Related Environmental Risks for Rheumatoid Arthritis.
Inhalant and Additional Mucosal-Related Environmental Risks for Rheumatoid Arthritis.
复制标题
DOI：
10.1016/j.rdc.2022.06.002
复制
发表时间：
2022-11
影响因子：
2.3
通讯作者：
England, Bryant R.
中科院分区：
文献类型：
--
作者：
Luedders, Brent A.;Mikuls, Ted R.;Thiele, Geoffrey M.;Poole, Jill A.;England, Bryant R.
关键词：
讨论越来越多的证据支持这一概念，即发生RA的风险是多因素的，并受到许多遗传和环境因素的影响(图1)。尤其是在携带HLA-DRB1风险等位基因的个体中，环境暴露和影响呼吸道的疾病是RA发生的主要危险因素，主导理论认为肺粘膜可能是RA自身免疫的起始部位。其他粘膜部位的暴露和疾病，包括口头总结吸入暴露，包括吸烟和各种其他职业和环境生物危害暴露，与发生类风湿关节炎的风险较高相关。同样，哮喘、慢性阻塞性肺病和感染等呼吸系统疾病与类风湿性关节炎风险有关，尽管这些疾病相对于导致这些疾病的环境暴露的相对贡献仍有待确定。呼吸道以外的疾病、牙周病以及口腔和牙周的改变
DiscussionMounting evidence supports the notion that the risk of developing RA is multifactorial and impacted by many genetic and environmental factors (Fig. 1). Particularly among individuals who carry HLA-DRB1 risk alleles, environmental exposures and diseases affecting the respiratory tract act as major risk factors for the development of RA, with a leading theory being that the lung mucosa may be an initial site of autoimmunity in RA. Exposures and diseases at other mucosal sites including the oralSummaryInhalant exposures including cigarette smoking and a variety of other occupational and environmental biohazard exposures are associated with a higher risk of developing RA. Similarly, respiratory diseases such as asthma, COPD, and infections have been linked to RA risk, though the relative contributions of these diseases versus the environmental exposures that led to these diseases largely remain to be determined. Beyond the respiratory tract, periodontal disease and alterations of the oral and
登录
查看更多内容
类风湿关节炎和骨关节炎口腔微生物组谱的变化以及关节炎筛查的潜在生物标志物
影响因子：
4.6
作者：
Chen B;Zhao Y;Li S;Yang L;Wang H;Wang T;Bin Shi;Gai Z;Heng X;Zhang C;Yang J;Zhang L
通讯作者：
Zhang L
简要报告：无关节炎受试者的气道异常和类风湿性关节炎相关自身抗体：早期损伤或自身免疫的起始部位？
影响因子：
--
作者：
Demoruelle, M. Kristen;Weisman, Michael H.;Simonian, Philip L.;Lynch, David A.;Sachs, Peter B.;Pedraza, Isabel F.;Harrington, Annie R.;Kolfenbach, Jason R.;Striebich, Christopher C.;Pham, Quyen N.;Strickland, Colin D.;Petersen, Brian D.;Parish, Mark C.;Derber, Lezlie A.;Norris, Jill M.;Holers, V. Michael;Deane, Kevin D.
通讯作者：
Deane, Kevin D.
影响因子：
4.7
作者：
Ilar, Anna;Alfredsson, Lars;Bengtsson, Camilla
通讯作者：
Bengtsson, Camilla
影响因子：
13.3
作者：
Artacho, Alejandro;Isaac, Sandrine;Scher, Jose U.
通讯作者：
Scher, Jose U.
DOI：
10.1097/jom.0b013e3182529799
发表时间：
2012-06-01
影响因子：
3.2
作者：
Jones, Kelly A.;Smith, Besa;Smith, Tyler C.
通讯作者：
Smith, Tyler C.