Variations in oral microbiome profiles in rheumatoid arthritis and osteoarthritis with potential biomarkers for arthritis screening.
Variations in oral microbiome profiles in rheumatoid arthritis and osteoarthritis with potential biomarkers for arthritis screening.
复制标题
类风湿关节炎和骨关节炎口腔微生物组谱的变化以及关节炎筛查的潜在生物标志物
DOI：
10.1038/s41598-018-35473-6
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发表时间：
2018-11-20
影响因子：
4.6
通讯作者：
Zhang L
中科院分区：
文献类型：
--
作者：
Chen B;Zhao Y;Li S;Yang L;Wang H;Wang T;Bin Shi;Gai Z;Heng X;Zhang C;Yang J;Zhang L
关节炎管理的关键是早期诊断和治疗，以防止进一步的关节破坏和最大限度地提高功能能力。骨关节炎（OA）和类风湿性关节炎（RA）是两种常见的关节炎类型，初级保健提供者必须在诊断和治疗方面加以区分。迫切需要有效和非侵入性的早期检测和疾病识别策略。越来越多的证据表明，RA与口腔微生物组相关，并可能受到其动态变化的影响。已经有一项研究比较了RA和OA患者的口腔微生物组，但是，它没有筛选关节炎的潜在生物标志物。在这项研究中，我们使用16S rRNA基因扩增子测序评估了110名RA患者，67名OA患者和155名健康受试者唾液样本中的口腔微生物组。分析了RA、OA和健康受试者口腔微生物组的结构和差异。八个口腔细菌生物标志物被确定为区分RA从OA。该报告提供了口腔微生物群的证据，作为发现关节炎筛查的非侵入性生物标志物的信息来源。
The key to arthritis management is early diagnosis and treatment to prevent further joint destruction and maximize functional ability. Osteoarthritis (OA) and rheumatoid arthritis (RA) are two common types of arthritis that the primary care provider must differentiate, in terms of diagnosis and treatment. Effective and non-invasive strategies for early detection and disease identification are sorely needed. Growing evidence suggests that RA has a correlation with oral microbiome and may be affected by its dynamic variations. There is already a study comparing oral microbiome in patients with RA and OA, however, it did not screen for potential biomarkers for arthritis. In this study, we assessed the oral microbiome in saliva samples from 110 RA patients, 67 OA patients and 155 healthy subjects, using 16S rRNA gene amplicon sequencing. The structure and differences in oral microbiome between RA, OA and healthy subjects were analyzed. Eight oral bacterial biomarkers were identified to differentiate RA from OA. This report provides proof of oral microbiota as an informative source for discovering non-invasive biomarkers for arthritis screening.
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DOI：
10.1177/1535370216681549
发表时间：
2017-02
期刊：
Experimental biology and medicine (Maywood, N.J.)
影响因子：
--
作者：
Pretorius E;Akeredolu OO;Soma P;Kell DB
通讯作者：
Kell DB
影响因子：
9.2
作者：
Hall MW;Singh N;Ng KF;Lam DK;Goldberg MB;Tenenbaum HC;Neufeld JD;G Beiko R;Senadheera DB
通讯作者：
Senadheera DB
影响因子：
3.7
作者：
Gomez A;Luckey D;Yeoman CJ;Marietta EV;Berg Miller ME;Murray JA;White BA;Taneja V
通讯作者：
Taneja V
影响因子：
2.3
作者：
Haraldsson, G;Meurman, JH;Holbrook, WP
通讯作者：
Holbrook, WP
影响因子：
3.1
作者：
Han, YW;Shi, WY;Genco, RJ
通讯作者：
Genco, RJ