Nanomaterials Manipulate Macrophages for Rheumatoid Arthritis Treatment.
Nanomaterials Manipulate Macrophages for Rheumatoid Arthritis Treatment.
复制标题
纳米材料操纵巨噬细胞治疗类风湿关节炎
DOI：
10.3389/fphar.2021.699245
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发表时间：
2021
影响因子：
5.6
通讯作者：
Liu JX
中科院分区：
文献类型：
--
作者：
Li S;Su J;Cai W;Liu JX
类风湿性关节炎（RA）是一种慢性、进行性、全身性的炎症性自身免疫性疾病，以滑膜炎症、滑膜衬里增生和炎性细胞浸润、自身抗体产生和软骨/骨破坏为特征。巨噬细胞是RA病理过程中的重要效应细胞，可与T、B和成纤维细胞样滑膜细胞相互作用，产生大量细胞因子、趋化因子、消化酶、类胡萝卜素和活性氧，加速骨破坏。因此，使用纳米材料靶向巨噬细胞对RA具有深远的治疗意义。目前对RA患者的临床治疗存在许多局限性，包括严重的副作用和选择性差，以及需要频繁给予治疗剂和高剂量药物。这些挑战鼓励了靶向药物递送系统的发展及其在RA治疗中的应用。近年来，通过静脉注射（主动或被动靶向）、口服、经皮吸收、腹腔注射和关节内注射，使用各种类型的纳米材料操纵巨噬细胞，对类风湿关节炎有明显的治疗效果，具有高精度靶向巨噬细胞和关节滑膜组织等优点。本文就纳米材料操纵巨噬细胞的机制进行了综述，并对其临床应用前景进行了展望。本文旨在为目前基于巨噬细胞靶向治疗类风湿关节炎的研究提供参考。
Rheumatoid arthritis (RA) is a chronic, progressive, and systemic inflammatory autoimmune disease, characterized by synovial inflammation, synovial lining hyperplasia and inflammatory cell infiltration, autoantibody production, and cartilage/bone destruction. Macrophages are crucial effector cells in the pathological process of RA, which can interact with T, B, and fibroblast-like synovial cells to produce large amounts of cytokines, chemokines, digestive enzymes, prostaglandins, and reactive oxygen species to accelerate bone destruction. Therefore, the use of nanomaterials to target macrophages has far-reaching therapeutic implications for RA. A number of limitations exist in the current clinical therapy for patients with RA, including severe side effects and poor selectivity, as well as the need for frequent administration of therapeutic agents and high doses of medication. These challenges have encouraged the development of targeting drug delivery systems and their application in the treatment of RA. Recently, obvious therapeutic effects on RA were observed following the use of various types of nanomaterials to manipulate macrophages through intravenous injection (active or passive targeting), oral administration, percutaneous absorption, intraperitoneal injection, and intra-articular injection, which offers several advantages, such as high-precision targeting of the macrophages and synovial tissue of the joint. In this review, the mechanisms involved in the manipulation of macrophages by nanomaterials are analyzed, and the prospect of clinical application is also discussed. The objective of this article was to provide a reference for the ongoing research concerning the treatment of RA based on the targeting of macrophages.
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