Retinal arteriolar parameters as a surrogate marker of intracranial vascular pathology.
Retinal arteriolar parameters as a surrogate marker of intracranial vascular pathology.
复制标题
视网膜小动脉参数是颅内血管病理的替代标记。
DOI：
10.1002/dad2.12338
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发表时间：
2022
影响因子：
5.3
通讯作者：
Green, Ari J.
中科院分区：
文献类型：
--
作者：
Abdelhak, Ahmed;Solomon, Isaac;Montes, Shivany Condor;Saias, Alexandra;Cordano, Christian;Asken, Breton;Fonseca, Corrina;Oertel, Frederike Cosima;Arfanakis, Konstantinos;Staffaroni, Adam M.;Kramer, Joel H.;Geschwind, Michael;Miller, Bruce L.;Elahi, Fanny M.;Green, Ari J.
关键词：
开发新的诊断工具是血管性痴呆的首要研究重点。一个主要的障碍是缺乏一种简单的，非侵入性的方法来可视化体内脑小动脉壁。视网膜小动脉为大脑循环提供了一个窗口。 应用光学相干断层扫描（I-bRAVO）中基于强度的视网膜小动脉可视化，评价250例散发性和遗传性脑小血管病（CSVD）、非血管性神经退行性疾病（NVND）和健康对照（HC）受试者的平均壁厚（MWT）和壁腔比（WLR），并结合成像和认知标志物。CSVD的MWT和WLR较高，与血管白色病变的严重程度相关，并与基于磁共振成像的颅内小动脉硬化评分相关。WLR与灰色和白色物质体积相关，并将无症状散发性CSVD与HC区分开来（曲线下面积= 0.82）。I-bRAVO是一种快速、无创的工具。MWT和WLR与CSVD的影像学标志物相关，有助于早期发现散发性CSVD。
Development of novel diagnostic tools is a top research priority in vascular dementia. A major obstacle is the lack of a simple, non‐invasive method to visualize cerebral arteriolar walls in vivo. Retinal arterioles offer a window into the cerebral circulation. Intensity‐based retinal arteriolar visualization in optical coherence tomography (I‐bRAVO) was applied to evaluate mean wall thickness (MWT) and wall‐to‐lumen ratio (WLR) in 250 subjects with sporadic and genetic cerebral small vessel disease (CSVD), non‐vascular neurodegenerative diseases (NVND), and healthy controls (HC) in association with imaging and cognitive markers. MWT and WLR were higher in CSVD, associated with severity of vascular white matter lesions, and correlated with magnetic resonance imaging‐based intracranial arteriolosclerosis score. WLR correlated with gray and white matter volume and differentiated asymptomatic sporadic CSVD from HC (area under the curve = 0.82). I‐bRAVO is a rapid, non‐invasive tool. MWT and WLR were associated with imaging markers of CSVD and could contribute to early identification of sporadic CSVD.
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DOI：
10.1002/alz.12221
发表时间：
2021-04
期刊：
Alzheimer's & dementia : the journal of the Alzheimer's Association
影响因子：
--
作者：
Hamilton OKL;Backhouse EV;Janssen E;Jochems ACC;Maher C;Ritakari TE;Stevenson AJ;Xia L;Deary IJ;Wardlaw JM
通讯作者：
Wardlaw JM
DOI：
10.1016/j.nicl.2021.102768
发表时间：
2021
期刊：
NeuroImage. Clinical
影响因子：
--
作者：
Makkinejad N;Evia AM;Tamhane AA;Javierre-Petit C;Leurgans SE;Lamar M;Barnes LL;Alzheimer's Disease Neuroimaging Initiative;Bennett DA;Schneider JA;Arfanakis K
通讯作者：
Arfanakis K
影响因子：
5.7
作者：
Malone IB;Leung KK;Clegg S;Barnes J;Whitwell JL;Ashburner J;Fox NC;Ridgway GR
通讯作者：
Ridgway GR
影响因子：
--
作者：
Dumitrascu OM;Qureshi TA
通讯作者：
Qureshi TA
影响因子：
5.6
作者：
Moss HE
通讯作者：
Moss HE