Small Non-Coding RNAs: New Insights in Modulation of Host Immune Response by Intracellular Bacterial Pathogens.
Small Non-Coding RNAs: New Insights in Modulation of Host Immune Response by Intracellular Bacterial Pathogens.
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小非编码 RNA：细胞内细菌病原体调节宿主免疫反应的新见解。
DOI：
10.3389/fimmu.2016.00431
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发表时间：
2016
影响因子：
7.3
通讯作者：
Liu ZF
中科院分区：
文献类型：
--
作者：
Ahmed W;Zheng K;Liu ZF
病原菌具有复杂的调控网络，在时间上控制毒力因子的产生，并使细菌能够在宿主细胞内存活和增殖。小分子非编码RNA（Small non-coding RNAs，sRNA）是基因表达的重要调控因子。最近的研究表明，细菌sRNA通过调节蛋白质-蛋白质相互作用或通过其与RNA和DNA碱基配对的能力参与生长和发育、细胞增殖、分化、代谢、细胞信号传导和免疫应答。在这篇综述中，我们简要概述了免疫相关sRNAs的作用机制，它们在免疫中的已知功能，以及它们如何被整合到控制毒力的调节回路中，这将有助于我们理解致病机理并开发新的，更有效的治疗方法来治疗细胞内细菌病原体引起的感染。
Pathogenic bacteria possess intricate regulatory networks that temporally control the production of virulence factors and enable the bacteria to survive and proliferate within host cell. Small non-coding RNAs (sRNAs) have been identified as important regulators of gene expression in diverse biological contexts. Recent research has shown bacterial sRNAs involved in growth and development, cell proliferation, differentiation, metabolism, cell signaling, and immune response through regulating protein–protein interactions or via their ability to base pair with RNA and DNA. In this review, we provide a brief overview of mechanism of action employed by immune-related sRNAs, their known functions in immunity, and how they can be integrated into regulatory circuits that govern virulence, which will facilitate our understanding of pathogenesis and the development of novel, more effective therapeutic approaches to treat infections caused by intracellular bacterial pathogens.
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