Genetic diversity among Bolivian arenaviruses.

Genetic diversity among Bolivian arenaviruses.
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DOI:
10.1016/j.virusres.2008.10.016
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发表时间:
2009-03
期刊:
影响因子:
5
通讯作者:
Fulhorst, Charles F.
Fulhorst, Charles F.
中科院分区:
医学3区
文献类型:
--
作者:
Cajimat, Maria N. B.;Milazzo, Mary Louise;Rollin, Pierre E.;Nichol, Stuart T.;Bowen, Michael D.;Ksiazek, Thomas G.;Fulhorst, Charles F.

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马丘波病毒和查帕雷病毒是Tacaribe血清复合体(沙粒病毒科病毒)的成员,也是玻利维亚人类出血热的病原。测定了8株马丘波病毒Z基因全序列、RNA依赖RNA聚合酶基因大片段、糖蛋白前体全基因和核衣壳蛋白全基因的核苷酸序列,以增加我们对玻利维亚沙粒病毒遗传多样性的认识。马丘波病毒株和查帕雷病毒株200001071的糖蛋白预测氨基酸序列分析结果表明,从马丘波病毒引起的出血热病例中提取的免疫血浆可能对玻利维亚出血热有益,而对查帕雷病毒引起的出血热无效。
Machupo virus and Chapare virusare members of the Tacaribe serocomplex (virus family Arenaviridae) and etiological agents of hemorrhagic fever in humans in Bolivia. The nucleotide sequences of the complete Z genes, a large fragment of the RNA-dependent RNA polymerase genes, the complete glycoprotein precursor genes, and the complete nucleocapsid protein genes of 8 strains of Machupo virus were determined to increase our knowledge of the genetic diversity among the Bolivian arenaviruses. The results of analyses of the predicted amino acid sequences of the glycoproteins of the Machupo virus strains and Chapare virus strain 200001071 indicated that immune plasma from hemorrhagic fever cases caused by Machupo virus may prove beneficial in the treatment of Bolivian hemorrhagic fever but not hemorrhagic fever caused by Chapare virus.
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发表时间: 1984-01-01
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