Prospective study of the relationship between coffee and tea with colorectal cancer risk: the PLCO Cancer Screening Trial.
Prospective study of the relationship between coffee and tea with colorectal cancer risk: the PLCO Cancer Screening Trial.
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DOI：
10.1038/bjc.2013.434
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发表时间：
2013-09-03
影响因子：
8.8
通讯作者：
Ahn J
中科院分区：
文献类型：
--
作者：
Dominianni C;Huang WY;Berndt S;Hayes RB;Ahn J
咖啡和茶通常被消费，并携带可能降低结直肠癌风险的潜在抗癌成分;然而，它们与结直肠癌风险的关系仍然不一致。进行了一项前瞻性分析，以检查咖啡和茶摄入量与结直肠癌风险之间的关系，该研究在国家癌症研究所前列腺，肺癌，结直肠癌和卵巢癌筛查试验的干预组中有57398名男性和女性，这是一项限制差异检测偏倚的国家筛查研究。咖啡和茶的摄入量通过食物频率问卷进行评估。在中位随访11.4年期间，确定了681例结肠直肠癌病例。更多的咖啡摄入与结直肠癌的风险无关（相对危险度（RR）=1.08，95%置信区间（CI）=0.79-1.48，Ptrend=0.23）。按癌症部位（P异质性=0.48）或分期（P异质性=0.83）分层并没有改变这种关系。无论是含咖啡因或不含咖啡因的咖啡，还是按几个结直肠癌风险因素分层，参与者的亚组中的相关性保持不变。同样，更多的茶摄入量与结直肠癌风险总体（RR=0.77，95% CI=0.55-1.09，P趋势=0.17）或癌症部位（P异质性=0.14）或阶段（P异质性=0.60）无关。这些相关性没有被几个结直肠癌风险因素改变。这项研究的结果并没有提供证据表明喝咖啡或茶有助于预防结直肠癌。
Coffee and tea are commonly consumed and carry potential anticancer components that could reduce the risk of colorectal cancer; however, their relationships with colorectal cancer risk remain inconsistent. A prospective analysis was carried out to examine the relationships of coffee and tea intake with colorectal cancer risk in 57 398 men and women in the intervention arm of the National Cancer Institute-Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial, a national screening study that limits differential detection biases. Coffee and tea intakes were assessed by food frequency questionnaire. Six hundred and eighty-one incident colorectal cancer cases were ascertained during a median follow-up of 11.4 years. Greater coffee intake was not associated with risk of colorectal cancer (relative risk (RR)=1.08, 95% confidence interval (CI)=0.79–1.48, Ptrend=0.23). Stratifying by cancer site (Pheterogeneity=0.48) or stage (Pheterogeneity=0.83) did not alter the relationship. Associations remained unchanged in subsets of participants for either caffeinated or decaffeinated coffee or when stratifying by several colorectal cancer risk factors. Similarly, greater tea intake was not associated with colorectal cancer risk overall (RR=0.77, 95% CI=0.55–1.09, Ptrend=0.17) or by cancer site (Pheterogeneity=0.14) or stage (Pheterogeneity=0.60). These associations were not modified by several colorectal cancer risk factors. The findings of this study do not provide evidence to suggest that drinking coffee or tea is beneficial in protecting against colorectal cancer.
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影响因子：
6.1
作者：
Bernstein, Carol;Holubec, Hana;Bhattacharyya, Achyut K.;Huy Nguyen;Payne, Claire M.;Zaitlin, Beryl;Bernstein, Harris
通讯作者：
Bernstein, Harris
影响因子：
10.3
作者：
Goldbohm, RA;Hertog, MGL;vandenBrandt, PA
通讯作者：
vandenBrandt, PA
影响因子：
6.1
作者：
del Castillo, MLR;Herraiz, M;Blanch, GP
通讯作者：
Blanch, GP
影响因子：
2.3
作者：
Galeone, Carlotta;Turati, Federica;Tavani, Alessandra
通讯作者：
Tavani, Alessandra
影响因子：
3.3
作者：
Shimizu, Masahito;Shirakami, Yohei;Moriwaki, Hisataka
通讯作者：
Moriwaki, Hisataka