Fungal Toxins and Host Immune Responses.
Fungal Toxins and Host Immune Responses.
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DOI：
10.3389/fmicb.2021.643639
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发表时间：
2021
影响因子：
5.2
通讯作者：
Richardson JP
中科院分区：
文献类型：
--
作者：
Brown R;Priest E;Naglik JR;Richardson JP
真菌是普遍存在的生物体，在包括土壤、植物、动物和人体在内的各种自然环境中茁壮成长。为了应对温暖，湿度和水分，某些生长在作物和收获的食品上的真菌会产生真菌毒素;当摄入时会对健康产生有害影响的次级代谢产物。正在进行的研究表明，在人类和实验模型的活动性真菌感染过程中也会产生一些真菌毒素，最近还产生肽毒素。先天性和适应性免疫识别的组合允许宿主从体内消除入侵的病原体。然而，免疫稳态的不平衡常常促进微生物感染。尽管真菌毒素对健康有广泛的影响，但我们对毒素介导的免疫反应调节的理解是不完整的。本文将探讨目前的理解真菌毒素，以及它们如何有助于调节宿主免疫。
Fungi are ubiquitous organisms that thrive in diverse natural environments including soils, plants, animals, and the human body. In response to warmth, humidity, and moisture, certain fungi which grow on crops and harvested foodstuffs can produce mycotoxins; secondary metabolites which when ingested have a deleterious impact on health. Ongoing research indicates that some mycotoxins and, more recently, peptide toxins are also produced during active fungal infection in humans and experimental models. A combination of innate and adaptive immune recognition allows the host to eliminate invading pathogens from the body. However, imbalances in immune homeostasis often facilitate microbial infection. Despite the wide-ranging effects of fungal toxins on health, our understanding of toxin-mediated modulation of immune responses is incomplete. This review will explore the current understanding of fungal toxins and how they contribute to the modulation of host immunity.
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