Within- and across-network alterations of the sensorimotor network in Parkinson's disease.
Within- and across-network alterations of the sensorimotor network in Parkinson's disease.
复制标题
帕金森病感觉运动网络的内部和跨网络改变
DOI：
10.1007/s00234-021-02731-w
复制
发表时间：
2021-12
期刊：
影响因子：
2.8
通讯作者：
Mathys C
中科院分区：
文献类型：
--
作者：
Caspers J;Rubbert C;Eickhoff SB;Hoffstaedter F;Südmeyer M;Hartmann CJ;Sigl B;Teichert N;Aissa J;Turowski B;Schnitzler A;Mathys C
Parkinson’s disease (PD) is primarily defined by motor symptoms and is associated with alterations of sensorimotor areas. Evidence for network changes of the sensorimotor network (SMN) in PD is inconsistent and a systematic evaluation of SMN in PD yet missing. We investigate functional connectivity changes of the SMN in PD, both, within the network, and to other large-scale connectivity networks. Resting-state fMRI was assessed in 38 PD patients under long-term dopaminergic treatment and 43 matched healthy controls (HC). Independent component analysis (ICA) into 20 components was conducted and the SMN was identified within the resulting networks. Functional connectivity within the SMN was analyzed using a dual regression approach. Connectivity between the SMN and the other networks from group ICA was investigated with FSLNets. We investigated for functional connectivity changes between patients and controls as well as between medication states (OFF vs. ON) in PD and for correlations with clinical parameters. There was decreased functional connectivity within the SMN in left inferior parietal and primary somatosensory cortex in PD OFF. Across networks, connectivity between SMN and two motor networks as well as two visual networks was diminished in PD OFF. All connectivity decreases partially normalized in PD ON. PD is accompanied by functional connectivity losses of the SMN, both, within the network and in interaction to other networks. The connectivity changes in short- and long-range connections are probably related to impaired sensory integration for motor function in PD. SMN decoupling can be partially compensated by dopaminergic therapy. The online version contains supplementary material available at 10.1007/s00234-021-02731-w.
登录
查看更多内容
DOI：
10.1073/pnas.0504136102
发表时间：
2005-07-05
影响因子：
11.1
作者：
Fox, MD;Snyder, AZ;Raichle, ME
通讯作者：
Raichle, ME
影响因子：
3.1
作者：
Caspers, Julian;Zilles, Karl;Eickhoff, Simon B.;Schleicher, Axel;Mohlberg, Hartmut;Amunts, Katrin
通讯作者：
Amunts, Katrin
影响因子：
4.8
作者：
Canu, Elisa;Agosta, Federica;Filippi, Massimo
通讯作者：
Filippi, Massimo
DOI：
10.1098/rstb.2005.1634
发表时间：
2005-05-29
影响因子：
6.3
作者：
Beckmann, CF;DeLuca, M;Smith, SM
通讯作者：
Smith, SM
影响因子：
4.8
作者：
Baggio, Hugo-Cesar;Sala-Llonch, Roser;Junque, Carme
通讯作者：
Junque, Carme