Inhibitory Effects of Apigenin on Tumor Carcinogenesis by Altering the Gut Microbiota.
Inhibitory Effects of Apigenin on Tumor Carcinogenesis by Altering the Gut Microbiota.
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DOI：
10.1155/2020/7141970
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发表时间：
2020
影响因子：
4.6
通讯作者：
Wang W
中科院分区：
文献类型：
--
作者：
Bian S;Wan H;Liao X;Wang W
类黄酮芹菜素是常见的许多植物。尽管相关机制尚未阐明，但芹菜素在体外和体内均表现出肿瘤抑制作用。本研究使用氧化偶氮甲烷（AOM）/右旋糖酐硫酸钠（DSS）诱导的结肠癌小鼠模型来研究芹菜素通过其对肠道微生物群的影响而发挥的潜在作用机制。在芹菜素治疗组中，肿瘤的大小和数量显著减少。使用粪便样品的16 S rRNA高通量测序，芹菜素显著影响肠道微生物群的组成。减少肠道微生物群并移植粪便的进一步实验提供了芹菜素调节的肠道微生物群发挥抗肿瘤作用的进一步证据。当肠道微生物群耗尽时，芹菜素无法减少肿瘤的数量或大小。此外，肿瘤抑制作用开始后，移植的粪便与芹菜素治疗的小鼠。我们的研究结果表明，芹菜素对肠道微生物群组成的影响可以抑制肿瘤。
The flavonoid apigenin is common to many plants. Although the responsible mechanisms have yet to be elucidated, apigenin demonstrates tumor suppression in vitro and in vivo. This study uses an azoxymethane (AOM)/dextran sodium sulfate- (DSS-) induced colon cancer mouse model to investigate apigenin's potential mechanism of action exerted through its effects upon gut microbiota. The size and quantity of tumors were reduced significantly in the apigenin treatment group. Using 16S rRNA high-throughput sequencing of fecal samples, the composition of gut microbiota was significantly affected by apigenin. Further experiments in which gut microbiota were reduced and feces were transplanted provided further evidence of apigenin-modulated gut microbiota exerting antitumor effects. Apigenin was unable to reduce the number or size of tumors when gut microbiota were depleted. Moreover, tumor inhibition effects were initiated following the transplant of feces from mice treated with apigenin. Our findings suggest that the effect of apigenin on the composition of gut microbiota can suppress tumors.
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影响因子：
64.8
作者：
通讯作者：
--
DOI：
10.3390/molecules15128602
发表时间：
2010-11-29
期刊：
Molecules (Basel, Switzerland)
影响因子：
--
作者：
Fu L;Xu BT;Xu XR;Qin XS;Gan RY;Li HB
通讯作者：
Li HB
影响因子：
24.5
作者：
Flemer B;Lynch DB;Brown JM;Jeffery IB;Ryan FJ;Claesson MJ;O'Riordain M;Shanahan F;O'Toole PW
通讯作者：
O'Toole PW
影响因子：
5.4
作者：
Kuo, Chao-Hung;Weng, Bi-Chuang;Wang, Yuan-Chuen
通讯作者：
Wang, Yuan-Chuen
影响因子：
3.7
作者：
Shukla, Sanjeev;Gupta, Sanjay
通讯作者：
Gupta, Sanjay