Mortality related to actigraphic long and short sleep.
Mortality related to actigraphic long and short sleep.
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DOI：
10.1016/j.sleep.2010.04.016
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发表时间：
2011-01
期刊：
影响因子：
4.8
通讯作者：
Rex, Katharine M.
中科院分区：
文献类型：
--
作者：
Kripke, Daniel F.;Langer, Robert D.;Elliott, Jeffrey A.;Klauber, Melville R.;Rex, Katharine M.
人们认为我们应该睡8个小时，这似乎是不正确的。许多研究表明，自我报告的睡眠时间超过7.5小时或短于6.5小时预示着死亡风险增加。这项研究检查了通过腕动计估计的前瞻性确定的客观睡眠时间是否与死亡风险相关。从1995年至1999年，平均年龄为67.6岁的妇女提供了一周的活动记录。从随访持续到2009年，可以估计444例患者的生存期，删失前平均为10.5年。多变量年龄分层考克斯回归模型控制了高血压、糖尿病、心肌梗死、癌症和重度抑郁症的病史。校正的生存函数估计61%的生存率（54%-69%，95% CI）睡眠时间少于300 min者生存率为78%（73%-85%，95%CI.）对于活动记录睡眠时间超过390分钟的患者，与90%（85%-94%，95% CI）的存活率相比，睡眠时间、睡眠效率和褪黑激素代谢产物排泄时间也是显著的死亡危险因素。这项研究证实了生存率和活动度测量的睡眠持续时间之间的U形关系，最佳客观睡眠持续时间比自我报告的最佳时间短。睡五六个小时的人可能会放心。需要进一步的研究来确定这种死亡率的任何可改变的因素和可能的预防方法。
The folk belief that we should sleep 8 hours seems to be incorrect. Numerous studies have shown that self-reported sleep longer than 7.5 hours or shorter than 6.5 hours predicts increased mortality risk. This study examined if prospectively-determined objective sleep duration, as estimated by wrist actigraphy, was associated with mortality risks. From 1995–1999, women averaging 67.6 years of age provided one-week actigraphic recordings. Survival could be estimated from follow-up continuing until 2009 for 444, with an average of 10.5 years before censoring. Multivariate age-stratified Cox regression models were controlled for history of hypertension, diabetes, myocardial infarction, cancer, and major depression. Adjusted survival functions estimated 61% survival (54%–69%, 95% C.I.) for those with sleep less than 300 min and 78% survival (73%–85%, 95% C.I.) for those with actigraphic sleep longer than 390 min, as compared with survival of 90% (85%–94%, 95% C.I.) for those with sleep of 300–390 min. Time-in-bed, sleep efficiency and the timing of melatonin metabolite excretion were also significant mortality risk factors. This study confirms a U-shaped relationship between survival and actigraphically measured sleep durations, with the optimal objective sleep duration being shorter than the self-report optimums. People who sleep five or six hours may be reassured. Further studies are needed to identify any modifiable factors for this mortality and possible approaches to prevention.
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