Untargeted metabolite profiling of serum in rats exposed to pyrraline
Untargeted metabolite profiling of serum in rats exposed to pyrraline
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暴露于吡咯啉的大鼠血清的非靶向代谢物分析
DOI：
10.1007/s10068-023-01256-7
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发表时间：
2023-01
影响因子：
2.9
通讯作者：
Baoguo Sun
中科院分区：
文献类型：
--
作者：
Chuanqin Hu;Jiahui Wang;Fangyuan Qi;Yingli Liu;Fen Zhao;Jing Wang;Baoguo Sun
吡咯啉是高级糖基化终产物之一，是在高级美拉德反应中形成的。据报道，吡咯啉的存在经测试与肾病和糖尿病有关。吡咯啉可能会导致潜在的健康风险，因为许多现代饮食都是经过热处理的。在该研究中，采用超高效液相色谱-质谱联用的综合代谢组学方法评估吡咯啉对大鼠代谢的影响。 32 种代谢物被鉴定为差异代谢物。亚麻酸代谢、苯丙氨酸、酪氨酸和色氨酸生物合成、花生四烯酸代谢、酪氨酸代谢和甘油磷脂代谢是这一病理过程中的主要扰动网络。我们发现的差异代谢物和代谢途径为研究吡咯啉的毒性分子机制提供了新的见解。
Pyrraline, one of advanced glycation end-products, is formed in advanced Maillard reactions. It was reported that the presence of pyrraline was tested to be associated with nephropathy and diabetes. Pyrraline might result in potential health risks because many modern diets are heat processed. In the study, an integrated metabolomics by ultra-high-performance liquid chromatography with mass spectrometry was used to evaluate the effects of pyrraline on metabolism in rats. Thirty-two metabolites were identified as differential metabolites. Linolenic acid metabolism, phenylalanine, tyrosine and tryptophan biosynthesis, arachidonic acid metabolism, tyrosine metabolism and glycerophospholipid metabolism were the main perturbed networks in this pathological process. Differential metabolites and metabolic pathways we found give new insights into studying the toxic molecular mechanisms of pyrraline.
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影响因子：
5.1
作者：
Miao, Hua;Chen, Hua;Zhao, Ying-Yong
通讯作者：
Zhao, Ying-Yong
影响因子：
4.1
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Dong-Sheng Zhao;Li-Long Jiang;Ya-Xi Fan;Lingli Wang;Zhuo-Qing Li;W. Shi;Ping Li;Hui-Jun Li
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影响因子：
29
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Johnson CH;Dejea CM;Edler D;Hoang LT;Santidrian AF;Felding BH;Ivanisevic J;Cho K;Wick EC;Hechenbleikner EM;Uritboonthai W;Goetz L;Casero RA Jr;Pardoll DM;White JR;Patti GJ;Sears CL;Siuzdak G
通讯作者：
Siuzdak G
影响因子：
3.9
作者：
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通讯作者：
Sun, Baoguo