Effects of combining field strengths on auditory functional MRI group analysis: 1.5T and 3T.
Effects of combining field strengths on auditory functional MRI group analysis: 1.5T and 3T.
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DOI：
10.1002/jmri.22823
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发表时间：
2011-12
影响因子：
4.4
通讯作者：
Talavage, Thomas M.
中科院分区：
文献类型：
--
作者：
Han, Kihwan;Talavage, Thomas M.
评估组合从不同场强获取的功能 MRI 数据对群体分析的影响，作为每个场强下受试者数量的函数。 28 名受试者（3T 时 18 名）参与了一项听觉任务，即在与事件相关的设计中被动聆听 0.75 秒的爵士乐片段。将单受试者分析的结果组合起来，为来自 3T 和 1.5T 池的每个受试者的 8 名受试者的小组创建所有可能的受试者组合，包括 (3T/1.5T) 0/8、2/6、4/4、6/2 和 8/0 的受试者混合物。每个受试者排列的组分析表现通过接受者操作特征（ROC）曲线和激活重叠图来测量。虽然 ROC 曲线下面积、金标准区域的激活程度和激活可靠性随着 3T 受试者数量的增加而增加，但边际增益却下降。观察到不同混合物之间的 ROC 表现重叠，表明某些受试者组合的表现明显优于其他组合。对于激活检测，4/4 可以说是与仅 3T 组结果相当的最低混合水平。纳入 1.5T 数据并不一定会降低分组分析的有效性。发现较低的场强数据仅限制检测功率，但不影响特异性。在重新调整误差的范围内，这些结果还应扩展到对不同场强的主题混合物进行分组纵向分析。
To evaluate effects of combining functional MRI data acquired from different field strengths on group analysis as a function of the number of subjects at each field strength. 28 subjects (18 at 3T) participated in an auditory task of passively listening to a 0.75s segment of jazz music in an event-related design. Results of single-subject analysis were combined to create all possible subject combinations for a group size of 8 subjects from each of the 3T and 1.5T pools, comprising subject mixtures of (3T/1.5T) 0/8, 2/6, 4/4, 6/2 and 8/0. Group analysis performance of each subject permutation was measured by receiver operating characteristic (ROC) curves and activation overlap maps. While area under ROC curves, extent of activation in the gold standard region and reliability of activation increased with the number of 3T subjects, marginal gain decreased. ROC performance overlap across mixtures was observed, indicating that some combinations of subjects markedly outperformed others. For detection of activation, 4/4 was arguably the minimum mixture level that was comparable to 3T-only group results. Inclusion of 1.5T data does not necessarily reduce the validity of group analysis. Lower field strength data was found only to limit detection power, but did not affect specificity. Within the limits of realignment error, these results should also extend to group longitudinal analyses of subject mixtures from different field strengths.
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