Reproducibility of fMRI activations associated with auditory sentence comprehension.
Reproducibility of fMRI activations associated with auditory sentence comprehension.
复制标题
fMRI激活与听觉句子理解相关的可重复性。
DOI：
10.1016/j.neuroimage.2010.09.082
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发表时间：
2011-02-01
期刊：
影响因子：
5.7
通讯作者：
Talavage TM
中科院分区：
文献类型：
--
作者：
Gonzalez-Castillo J;Talavage TM
三个不同方面的功能磁共振成像激活，即二进制激活地图，效果大小和局部最大值的空间分布的再现性进行了评估，一组17名受试者，在五个不同的场合进行了扫描的听觉句子理解任务具有高的注意力需求。在扫描仪中，受试者被要求听纽约城市大学句子测试中的六个日常短句。在每个听力条件时期之后，通过让受试者回答一系列多项选择题来监测对刺激的理解和注意。在三个不同的水平上计算了听觉条件的激活统计图：所有成像会话的总体结果，五个成像场合中每个成像场合的组级/单会话结果，以及为每个受试者和每个扫描场合独立计算的单个受试者/单会话结果。实验任务招募了一个分布式的双边网络，处理节点位于外侧颞叶皮层，下额叶皮层，内侧BA 6，内侧枕叶皮层和皮层下结构，如壳核和丘脑。在组水平上这些激活的再现性很高（83.95%的成像体积在所有五个成像会话中始终被分类为活动/非活动），表明与听觉理解相关的神经元活动的部位可以可靠地用fMRI在健康受试者中检测到，在组平均后重复测量。在单个受试者水平的再现性范围从中等到高，虽然没有发现显着差异的行为措施，跨学科或会话。这一结果表明，上下文差异，即，这些特定于每个成像会话，可以调节我们检测与个体受试者的言语理解相关的功能磁共振成像激活的能力。
Reproducibility of three different aspects of fMRI activations—namely binary activation maps, effect size and spatial distribution of local maxima—was evaluated for an auditory sentence comprehension task with high attention demand on a group of 17 subjects that were scanned on five different occasions. While in the scanner subjects were asked to listen to series of six short everyday sentences from the CUNY sentence test. Comprehension and attention to the stimuli was monitored after each listen condition epoch by having subjects answer a series of multiple choice questions. Statistical maps of activation for the listen condition were computed at three different levels: overall results for all imaging sessions, group-level/single-session results for each of the five imaging occasions, and single-subject/single-session results computed for each subject and each scanning occasion independently. The experimental task recruited a distributed bilateral network with processing nodes located in lateral temporal cortex, inferior frontal cortex, medial BA6, medial occipital cortex and subcortical structures such as the putamen and the thalamus. Reproducibility of these activations at the group level was high (83.95% of the imaged volume was consistently classified as active/inactive across all five imaging sessions), indicating that sites of neuronal activity associated with auditory comprehension can reliably be detected with fMRI in healthy subjects, across repeated measures after group averaging. At the single-subject level reproducibility ranged from moderate to high, although no significant differences were found on behavioral measures across subjects or sessions. This result suggests that contextual differences—i.e., those specific to each imaging session, can modulate our ability to detect fMRI activations associated with speech comprehension in individual subjects.
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