Computational Modeling of the Liver Arterial Blood Flow for Microsphere Therapy: Effect of Boundary Conditions.
Computational Modeling of the Liver Arterial Blood Flow for Microsphere Therapy: Effect of Boundary Conditions.
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DOI：
10.3390/bioengineering7030064
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发表时间：
2020-06-29
期刊：
影响因子：
--
通讯作者：
Roncali E
中科院分区：
文献类型：
--
作者：
Taebi A;Pillai RM;Roudsari BS;Vu CT;Roncali E
经动脉栓塞是一种用于晚期肝癌的微创治疗方法，使用载有化疗药物或放射性钇-90（90 Y）的微球，通过导管注入肝动脉树。为了实现个性化治疗，应通过注射体积和位置优化微球在肝脏中的分布。计算流体动力学（CFD）模拟肝动脉中的血流可以帮助估计这种分布，如果仔细参数化。一个重要的方面是在计算域的入口和出口处施加的边界条件的选择。在这项研究中，边界条件对肝动脉树血流动力学的影响进行了研究。出口边界条件采用三元件Windkessel回路建模，代表下游血管阻力。结果表明，下游血管阻力影响肝动脉血流动力学，如速度场，压力场和血流流线轨迹。此外，随着下游阻力的变化，肿瘤接受的微球数量显著变化（超过总注射微球的10%）。这些结果表明，应使用患者特定的边界条件，以便在经动脉栓塞治疗计划中使用CFD实现更准确的药物分布估计。
Transarterial embolization is a minimally invasive treatment for advanced liver cancer using microspheres loaded with a chemotherapeutic drug or radioactive yttrium-90 (90Y) that are injected into the hepatic arterial tree through a catheter. For personalized treatment, the microsphere distribution in the liver should be optimized through the injection volume and location. Computational fluid dynamics (CFD) simulations of the blood flow in the hepatic artery can help estimate this distribution if carefully parameterized. An important aspect is the choice of the boundary conditions imposed at the inlet and outlets of the computational domain. In this study, the effect of boundary conditions on the hepatic arterial tree hemodynamics was investigated. The outlet boundary conditions were modeled with three-element Windkessel circuits, representative of the downstream vasculature resistance. Results demonstrated that the downstream vasculature resistance affected the hepatic artery hemodynamics such as the velocity field, the pressure field and the blood flow streamline trajectories. Moreover, the number of microspheres received by the tumor significantly changed (more than 10% of the total injected microspheres) with downstream resistance variations. These findings suggest that patient-specific boundary conditions should be used in order to achieve a more accurate drug distribution estimation with CFD in transarterial embolization treatment planning.
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影响因子：
3.8
作者：
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通讯作者：
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影响因子：
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作者：
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DOI：
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发表时间：
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影响因子：
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通讯作者：
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DOI：
10.1002/cnm.2983
发表时间：
2018-07-01
影响因子：
2.1
作者：
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通讯作者：
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影响因子：
2.7
作者：
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通讯作者：
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