The additive effect of late-life depression and olfactory dysfunction on the risk of dementia was mediated by hypersynchronization of the hippocampus/fusiform gyrus.
The additive effect of late-life depression and olfactory dysfunction on the risk of dementia was mediated by hypersynchronization of the hippocampus/fusiform gyrus.
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DOI：
10.1038/s41398-021-01291-0
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发表时间：
2021-03-17
影响因子：
6.8
通讯作者：
Ning Y
中科院分区：
文献类型：
--
作者：
Chen B;Zhong X;Zhang M;Mai N;Wu Z;Chen X;Peng Q;Zhou H;Wang Q;Yang M;Zhang S;Auber LA;Croy I;Hummel T;Ning Y
早期发现患有老年抑郁症（LLD）的患者，具有发展痴呆症的高风险，有助于早期干预。气味识别（OI）功能障碍可作为预测痴呆的标志物，但OI功能障碍是否会增加LLD患者患痴呆的风险仍不清楚。本研究旨在探讨LLD和OI功能障碍对痴呆风险及其潜在神经影像学变化的交互作用。157例LLD患者和101名正常对照者被招募，并收集他们的OI，认知，日常生活活动（ADL）和静息态功能磁共振成像的数据。采用2 × 2析因分析LLD和OI功能障碍对神经心理学和神经影像学异常的交互作用。中介分析用于探讨神经影像学检测到的异常是否介导了OI和认知/ADL之间的关联。结果表明，LLD和OI功能障碍对ADL、整体认知和记忆评分降低以及神经影像学变量（i）右侧眶额皮质和右侧中央前皮质低频波动分数振幅（fALFF）增加，（ii）左侧海马/梭状回区域均匀性（ReHo）增加等具有累加效应。这些增加的fALFF和ReHo值与降低的神经心理学评分（ADL、整体认知、记忆和语言）相关。左侧海马/梭状回ReHo完全介导OI与ADL的关系，部分介导OI与整体认知的关系。总体而言，通过左海马/梭状回的超同步化介导，OI功能障碍可能增加LLD患者痴呆的风险。
Early detection of patients with late-life depression (LLD) with a high risk of developing dementia contributes to early intervention. Odor identification (OI) dysfunction serves as a marker for predicting dementia, but whether OI dysfunction increases the risk of dementia in LLD patients remains unclear. The present study aimed to explore the interactive effect of LLD and OI dysfunction on the risk of dementia and its underlying neuroimaging changes. One hundred and fifty-seven LLD patients and 101 normal controls were recruited, and data on their OI, cognition, activity of daily living (ADL), and resting-state functional magnetic resonance imaging were collected. Two × two factorial analyses were used to analyze the interactive effects of LLD and OI dysfunction on neuropsychological and neuroimaging abnormalities. Mediation analyses were used to explore whether abnormalities detected by neuroimaging mediated the the associations between OI and cognition/ADL. The results suggested that LLD and OI dysfunction exhibited additive effects on reduced ADL, global cognition and memory scores, as well as neuroimaging variables including (i) increased fractional amplitude of low-frequency fluctuation (fALFF) in the right orbitofrontal cortex and right precentral cortex, and (ii) increased regional homogeneity (ReHo) in the left hippocampus/fusiform gyrus, etc. In addition, these increased fALFF and ReHo values were associated with reduced neuropsychological scores (ADL, global cognition, memory, and language). Moreover, ReHo of the left hippocampus/fusiform gyrus completely mediated the relationship between OI and ADL, and partially mediated the relationship between OI and global cognition. Overall, mediated by the hypersynchronization of the left hippocampus/fusiform gyrus, OI dysfunction may increase the risk of dementia in LLD patients.
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影响因子：
3.8
作者：
Ho TC;Zhang S;Sacchet MD;Weng H;Connolly CG;Henje Blom E;Han LK;Mobayed NO;Yang TT
通讯作者：
Yang TT
DOI：
10.1007/s00259-014-2975-4
发表时间：
2015-04
影响因子：
9.1
作者：
Brendel M;Pogarell O;Xiong G;Delker A;Bartenstein P;Rominger A;Alzheimer’s Disease Neuroimaging Initiative
通讯作者：
Alzheimer’s Disease Neuroimaging Initiative
影响因子：
5.7
作者：
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通讯作者：
Frasnelli, Johannes
影响因子：
4
作者：
Bahar-Fuchs, Alex;Chetelat, Gael;Savage, Greg
通讯作者：
Savage, Greg
影响因子：
14
作者：
Devanand, Davangere P.;Lee, Seonjoo;Mayeux, Richard
通讯作者：
Mayeux, Richard