Structure-function assessment in glaucoma based on perimetric sensitivity and en face optical coherence tomography images of retinal nerve fiber bundles.
Structure-function assessment in glaucoma based on perimetric sensitivity and en face optical coherence tomography images of retinal nerve fiber bundles.
复制标题
DOI：
10.1038/s41598-023-28917-1
复制
发表时间：
2023-02-13
影响因子：
4.6
通讯作者：
中科院分区：
文献类型：
--
作者：
许多研究评估了青光眼的结构-功能关系，但大多数没有在中央30°进行地形比较。我们提出了一种方法，用于评估结构与功能的关系与视网膜神经纤维层（RNFL）束的正面图像，允许地形比较在这个视网膜区域的大部分。招募了44名青光眼患者（中位年龄61岁），并进行了光学相干断层扫描（OCT）和视野检查。收集6个矩形容积扫描，然后进行剪辑，以提供RNFL束的正面视图。我们计算了显示周边缺陷的位置的比例，也显示了正面RNFL缺陷;以及落在RNFL缺陷上的位置的比例，也显示了周边缺陷。一个位置的周边缺损定义为总偏差（TD）值等于或大于-4 dB。我们发现，具有异常RNFL束反射率的位置的中位数（IQR）数量也具有异常TD为78%（60%），并且具有异常TD的位置也具有异常RNFL束反射率为75%（44%）。我们展示了一种潜在的方法，青光眼的结构功能评估，提出了地形反射图，确认以前的研究结果，包括更大的视网膜区域。
Many studies have assessed structure–function relations in glaucoma, but most without topographical comparison across the central 30°. We present a method for assessing structure–function relations with en face images of retinal nerve fiber layer (RNFL) bundles allowing topographical comparison across much of this retinal area. Forty-four patients with glaucoma (median age 61 years) were recruited and tested with Optical Coherence Tomography (OCT) and perimetry. Six rectangular volume scans were gathered, and then montaged to provide en face views of the RNFL bundles. We calculated the proportion of locations showing a perimetric defect that also showed an en face RNFL defect; and the proportion of locations falling on an RNFL defect that also showed a perimetric defect. A perimetric defect for a location was defined as a total deviation (TD) value equal to or deeper than -4 dB. We found that the median (IQR) number of locations with abnormal RNFL bundle reflectance that also had abnormal TD was 78% (60%) and for locations with abnormal TD that also had abnormal RNFL bundle reflectance was 75% (44%). We demonstrated a potential approach for structure–function assessment in glaucoma by presenting a topographic reflectance map, confirming results of previous studies and including larger retinal regions.
登录
查看更多内容
影响因子：
1.8
作者：
Orzalesi, N;Miglior, S;Rosetti, L
通讯作者：
Rosetti, L
DOI：
10.1097/opx.0000000000001690
发表时间：
2021-05-01
期刊：
Optometry and vision science : official publication of the American Academy of Optometry
影响因子：
--
作者：
Swanson WH;King BJ;Burns SA
通讯作者：
Burns SA
影响因子：
13.7
作者：
Christopher M;Bowd C;Belghith A;Goldbaum MH;Weinreb RN;Fazio MA;Girkin CA;Liebmann JM;Zangwill LM
通讯作者：
Zangwill LM
DOI：
10.1111/opo.12449
发表时间：
2018-07
期刊：
Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists)
影响因子：
--
作者：
Ashimatey BS;King BJ;Burns SA;Swanson WH
通讯作者：
Swanson WH
影响因子：
3
作者：
Cheloni R;Dewsbery SD;Denniss J
通讯作者：
Denniss J