Ultradian Rhythms in the Transcriptome of Neurospora crassa.
Ultradian Rhythms in the Transcriptome of Neurospora crassa.
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DOI：
10.1016/j.isci.2018.11.012
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发表时间：
2018-11-30
期刊：
影响因子：
5.8
通讯作者：
Herzel H
中科院分区：
文献类型：
--
作者：
Ananthasubramaniam B;Diernfellner A;Brunner M;Herzel H
在许多生物体中，生物钟驱动时钟控制的基因转录的节奏，这些基因既可以是昼夜节律(∼24小时周期)，也可以是超天周期(<；24小时周期)。周期小于24小时的超传统节奏称为和声。在小鼠肝脏中发现了几个谐波转录本，但它们的功能意义尚不清楚。利用基于模型的分析，我们首次报道了粗糙脉孢菌的∼7小时三次谐波转录本，这是一种公认的真菌昼夜节律模式生物体。几个三次谐波基因受雌性育性基因7(FF-7)的调控，其转录产物本身就是三次谐波。昼夜节律输出调节子CSP1的敲除将昼夜节律叠加在三次调和基因上，而应激反应调节子MSN1的敲除将三次调和节律转换为二次调和节律。460个∼7小时基因在小鼠肝脏中的两个反相组中以多种基因类型共同调节，包括激酶、染色质重构体和谐波基因的同源物。在真菌时钟模型生物体中共存的谐波∼7小时和昼夜节律输出调节子CSP1的敲除将昼夜节律强加于∼7小时节律三次谐波节律是关键细胞过程的一部分，由FF-7介导，7小时基因在两个反相簇中共同调节，跨基因和实验室生物科学；时间生物学；转录组学
In many organisms, the circadian clock drives rhythms in the transcription of clock-controlled genes that can be either circadian (∼24-hr period) or ultradian (<24-hr period). Ultradian rhythms with periods that are a fraction of 24 hr are termed harmonics. Several harmonic transcripts were discovered in the mouse liver, but their functional significance remains unclear. Using a model-based analysis, we report for the first time ∼7-hr third harmonic transcripts in Neurospora crassa, a well-established fungal circadian model organism. Several third harmonic genes are regulated by female fertility 7 (FF-7), whose transcript itself is third harmonic. The knockout of circadian output regulator CSP1 superimposes circadian rhythms on the third harmonic genes, whereas the knockout of stress response regulator MSN1 converts third harmonic rhythms to second harmonic rhythms. The 460 ∼7-hr genes are co-regulated in two anti-phasic groups in multiple genotypes and include kinases, chromatin remodelers, and homologs of harmonic genes in the mouse liver. Coexisting harmonic ∼7-hr and circadian rhythms in fungal clock model organism Knockout of output regulator CSP1 imposes circadian rhythms over ∼7-hr rhythms Third harmonic rhythms are a part of key cellular processes and mediated by FF-7 7-hr genes are co-regulated in two anti-phasic clusters across genotypes and laboratories Biological Sciences; Chronobiology; Transcriptomics
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影响因子：
5.4
作者：
Sancar C;Sancar G;Ha N;Cesbron F;Brunner M
通讯作者：
Brunner M
影响因子：
64.8
作者：
Bulla, Martin;Valcu, Mihai;Kempenaers, Bart
通讯作者：
Kempenaers, Bart
影响因子：
11.4
作者：
Chen, Chen-Hui;Ringelberg, Carol S.;Loros, Jennifer J.
通讯作者：
Loros, Jennifer J.
DOI：
10.1126/science.1257277
发表时间：
2015-01-30
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Larrondo LF;Olivares-Yañez C;Baker CL;Loros JJ;Dunlap JC
通讯作者：
Dunlap JC
影响因子：
3.7
作者：
Cesbron F;Brunner M;Diernfellner AC
通讯作者：
Diernfellner AC