A Mechanically-Adaptive Polymer Nanocomposite-Based Intracortical Probe and Package for Chronic Neural Recording.
A Mechanically-Adaptive Polymer Nanocomposite-Based Intracortical Probe and Package for Chronic Neural Recording.
复制标题
DOI：
10.3390/mi9110583
复制
发表时间：
2018-11-08
期刊：
影响因子：
3.4
通讯作者：
Tyler DJ
中科院分区：
文献类型：
--
作者：
Hess-Dunning A;Tyler DJ
机械、材料和生物原因导致的皮质内探针失效阻碍了它们在基础科学和临床应用中的应用。通过预测故障的原因，我们可以设计一个系统来防止已知的故障原因。神经探针的设计以一种仿生的、机械软化的聚合物纳米复合材料为中心。聚合物纳米复合材料的功能化采用微电极记录，微加工工艺设计为化学和热工艺的兼容性。一个基于带状电缆、印刷电路板和3d打印外壳的定制包装被设计为能够连接到外部电子设备。将探针植入Sprague-Dawley大鼠初级运动皮层16周，在此期间进行定期记录和电化学阻抗谱测量。植入的机械软化探针在16周内具有稳定的电化学阻抗谱，并且单个单元记录到16周。机械软化探针对慢性神经记录的证明表明，探针结构、定制包装和通用设计策略适合于啮齿动物的长期研究。
Mechanical, materials, and biological causes of intracortical probe failure have hampered their utility in basic science and clinical applications. By anticipating causes of failure, we can design a system that will prevent the known causes of failure. The neural probe design was centered around a bio-inspired, mechanically-softening polymer nanocomposite. The polymer nanocomposite was functionalized with recording microelectrodes using a microfabrication process designed for chemical and thermal process compatibility. A custom package based upon a ribbon cable, printed circuit board, and a 3D-printed housing was designed to enable connection to external electronics. Probes were implanted into the primary motor cortex of Sprague-Dawley rats for 16 weeks, during which regular recording and electrochemical impedance spectroscopy measurement sessions took place. The implanted mechanically-softening probes had stable electrochemical impedance spectra across the 16 weeks and single units were recorded out to 16 weeks. The demonstration of chronic neural recording with the mechanically-softening probe suggests that probe architecture, custom package, and general design strategy are appropriate for long-term studies in rodents.
登录
查看更多内容
基于层状硅的慢性植入平面硅探针的机械故障模式，用于层流记录。
影响因子：
14
作者：
Kozai, Takashi D. Y.;Catt, Kasey;Li, Xia;Gugel, Zhannetta V.;Olafsson, Valur T.;Vazquez, Alberto L.;Cui, X. Tracy
通讯作者：
Cui, X. Tracy
影响因子：
5
作者：
Capadona, Jeffrey R.;Tyler, Dustin J.;Weder, Christoph
通讯作者：
Weder, Christoph
影响因子：
5
作者：
Ferreira, Nuno R.;Ledo, Ana;Barbosa, Rui M.
通讯作者：
Barbosa, Rui M.
影响因子：
4.6
作者：
Cui, XY;Martin, DC
通讯作者：
Martin, DC
影响因子：
5.5
作者：
Dagnon, Koffi L.;Shanmuganathan, Kadhiravan;Rowan, Stuart J.
通讯作者：
Rowan, Stuart J.